Side effects across medicines
Medicines whose labels list drowsiness
657 medicines have an FDA label that names drowsiness (somnolence) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of drowsiness name pregabalin (11,824), gabapentin (9,817) and quetiapine (8,321), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list drowsiness?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 657 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of drowsiness |
|---|---|---|
| Furosemide | precautions | 5,550 |
| Diazepam | warnings (intramuscular/ | 5,078 |
| Diphenhydramine | precautions | 4,239 |
| Levetiracetam | warnings and precautions (intravenous label) | 4,175 |
| Baclofen | precautions (intrathecal label) | 2,766 |
| Hydrochlorothiazide | precautions | 2,397 |
| Carbidopa and levodopa | precautions | 2,007 |
| Valproic acid | warnings and precautions (intravenous label) | 1,277 |
| Methadone | precautions (intramuscular/ | 1,271 |
| Hydroxyzine | precautions | 1,135 |
| Acyclovir | precautions | 1,011 |
| Temazepam | precautions | 956 |
| Metoclopramide | precautions (intramuscular/ | 947 |
| Eszopiclone | warnings and precautions (oropharyngeal label) | 888 |
| Epinephrine and lidocaine | warnings and precautions (submucosal label) | 887 |
| Haloperidol | warnings (intramuscular label) | 842 |
| Fluconazole | precautions | 701 |
| Cyclosporine | precautions | 624 |
| Naltrexone | precautions | 587 |
| Midazolam | warnings (oral label) | 558 |
| Acetaminophen and hydrocodone | precautions | 557 |
| Methocarbamol | precautions | 483 |
| Oxybutynin | warnings (transdermal label) | 480 |
| Zonisamide | precautions | 467 |
| Promethazine | precautions | 402 |
| Progesterone | precautions | 384 |
| Doxepin | precautions | 371 |
| Prochlorperazine | warnings (intramuscular/ | 347 |
| Asenapine | warnings and precautions (transdermal label) | 325 |
| Buspirone | precautions | 273 |
| Acetaminophen and oxycodone | precautions | 269 |
| Loxapine | precautions | 255 |
| Chlorpromazine | warnings (intramuscular label) | 241 |
| Trimethobenzamide | warnings and precautions (oral label) | 228 |
| Atropine and diphenoxylate | precautions | 182 |
| Chlorthalidone | precautions | 170 |
| Hydrochlorothiazide and lisinopril | precautions | 162 |
| Metolazone | precautions | 145 |
| Acetazolamide | precautions | 143 |
| Linezolid | warnings and precautions (oral label) | 142 |
| Prazosin | precautions | 134 |
| Carbidopa | precautions | 125 |
| Glycopyrrolate | precautions | 119 |
| Hydrochlorothiazide and triamterene | precautions | 100 |
| Terazosin | precautions | 100 |
| Acetaminophen and caffeine and dihydrocodeine | precautions | none in the top 1,000 |
| Alprostadil | precautions (intravascular/ | none in the top 1,000 |
| Amiloride and hydrochlorothiazide | precautions | none in the top 1,000 |
| Amoxapine | precautions | none in the top 1,000 |
| Amoxicillin and clarithromycin and lansoprazole | precautions | none in the top 1,000 |
| Apraclonidine | precautions | none in the top 1,000 |
| Aspirin and oxycodone | precautions | none in the top 1,000 |
| Atenolol and chlorthalidone | precautions | none in the top 1,000 |
| Avapritinib | warnings and precautions | none in the top 1,000 |
| Bisoprolol and hydrochlorothiazide | precautions | none in the top 1,000 |
| Bupivacaine and epinephrine | precautions (submucosal label) | none in the top 1,000 |
| Butorphanol | precautions | none in the top 1,000 |
| Captopril and hydrochlorothiazide | precautions | none in the top 1,000 |
| Carbinoxamine | precautions | none in the top 1,000 |
| Chlordiazepoxide and clidinium | precautions | none in the top 1,000 |
| Chlorothiazide | precautions | none in the top 1,000 |
| Cycloserine | precautions | none in the top 1,000 |
| Cysteamine | warnings and precautions (oral label) | none in the top 1,000 |
| Dantrolene | warnings and precautions (intravenous label) | none in the top 1,000 |
| Dextromethorphan and promethazine | precautions | none in the top 1,000 |
| Enalapril and hydrochlorothiazide | precautions | none in the top 1,000 |
| Estazolam | precautions | none in the top 1,000 |
| Flavoxate | precautions | none in the top 1,000 |
| Fluphenazine | precautions (intramuscular/ | none in the top 1,000 |
| Foscarnet | precautions | none in the top 1,000 |
| Ganaxolone | warnings and precautions | none in the top 1,000 |
| Glipizide and metformin | precautions | none in the top 1,000 |
| Hydrochlorothiazide and spironolactone | precautions | none in the top 1,000 |
| Hydrocodone and ibuprofen | precautions | none in the top 1,000 |
| Ivermectin | warnings (oral label) | none in the top 1,000 |
| Laronidase | warnings and precautions | none in the top 1,000 |
| Levorphanol | precautions | none in the top 1,000 |
| Mepivacaine | precautions | none in the top 1,000 |
| Methohexital | precautions | none in the top 1,000 |
| Molindone | precautions | none in the top 1,000 |
| Mosunetuzumab | warnings and precautions (intravenous label) | none in the top 1,000 |
| Nefazodone | precautions | none in the top 1,000 |
| Olopatadine | warnings and precautions (nasal label) | none in the top 1,000 |
| Phenylephrine and promethazine | precautions | none in the top 1,000 |
| Pimozide | precautions | none in the top 1,000 |
| Rotigotine | warnings and precautions | none in the top 1,000 |
| Viloxazine | warnings and precautions | none in the top 1,000 |
| Zaleplon | precautions | none in the top 1,000 |
| Pregabalin | adverse reactions | 11,824 |
| Gabapentin | adverse reactions | 9,817 |
| Quetiapine | adverse reactions | 8,321 |
| Alprazolam | adverse reactions | 6,019 |
| Omeprazole | adverse reactions | 5,950 |
| Clonazepam | adverse reactions | 5,770 |
| Lamotrigine | adverse reactions | 4,506 |
| Risperidone | adverse reactions | 4,401 |
| Escitalopram | adverse reactions | 4,065 |
| Olanzapine | adverse reactions | 3,965 |
| Venlafaxine | adverse reactions | 3,894 |
| Zolpidem | adverse reactions | 3,773 |
| Amlodipine | adverse reactions | 3,683 |
| Aripiprazole | adverse reactions | 3,580 |
| Fluoxetine | adverse reactions | 3,446 |
| Metoprolol | adverse reactions | 3,444 |
| Albuterol | adverse reactions (oral label) | 3,302 |
| Citalopram | adverse reactions | 3,242 |
| Pantoprazole | adverse reactions | 3,161 |
| Oxycodone | adverse reactions | 3,140 |
| Mirtazapine | adverse reactions | 3,088 |
| Methotrexate | adverse reactions | 2,931 |
| Sertraline | adverse reactions | 2,907 |
| Topiramate | adverse reactions | 2,780 |
| Valbenazine | adverse reactions | 2,468 |
| Carbamazepine | adverse reactions | 2,388 |
| Clozapine | adverse reactions | 2,290 |
| Losartan | adverse reactions | 2,246 |
| Bupropion | adverse reactions | 2,187 |
| Fentanyl | adverse reactions | 2,128 |
| Atenolol | adverse reactions | 2,107 |
| Bisoprolol | adverse reactions | 2,070 |
| Duloxetine | adverse reactions | 2,012 |
| Morphine | adverse reactions | 1,961 |
| Clobazam | adverse reactions | 1,944 |
| Divalproex | adverse reactions | 1,900 |
| Methylphenidate | adverse reactions | 1,896 |
| Spironolactone | adverse reactions | 1,885 |
| Allopurinol | adverse reactions | 1,877 |
| Montelukast | adverse reactions | 1,847 |
| Varenicline | adverse reactions | 1,793 |
| Ramipril | adverse reactions | 1,766 |
| Diclofenac | adverse reactions (oral label) | 1,747 |
| Celecoxib | adverse reactions | 1,739 |
| Pimavanserin | adverse reactions | 1,733 |
| Carvedilol | adverse reactions | 1,719 |
| Buprenorphine | adverse reactions | 1,687 |
| Ondansetron | adverse reactions (intramuscular/ | 1,659 |
| Paroxetine | adverse reactions | 1,516 |
| Lacosamide | adverse reactions | 1,497 |
| Hydromorphone | adverse reactions | 1,393 |
| Natalizumab | adverse reactions | 1,366 |
| Donepezil | adverse reactions | 1,364 |
| Atomoxetine | adverse reactions | 1,360 |
| Cannabidiol | adverse reactions | 1,292 |
| Oxcarbazepine | adverse reactions | 1,236 |
| Clonidine | adverse reactions | 1,171 |
| Ranitidine | adverse reactions | 1,133 |
| Interferon beta 1a | adverse reactions | 1,098 |
| Lurasidone | adverse reactions | 1,076 |
| Lisdexamfetamine | adverse reactions | 1,065 |
| Tramadol | adverse reactions | 1,031 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most drowsiness reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Somnolence”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch