Side effects across medicines
Medicines whose labels list diarrhea
1,304 medicines have an FDA label that names diarrhea in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of diarrhea name lenalidomide (31,468), adalimumab (25,849) and omeprazole (25,415), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list diarrhea?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 151 of the 1,304 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of diarrhea |
|---|---|---|
| Methotrexate | boxed warning (subcutaneous label) | 20,705 |
| Clindamycin | boxed warning (intramuscular/ | 359 |
| Pantoprazole | warnings and precautions (intravenous label) | 17,555 |
| Esomeprazole | warnings and precautions (intravenous label) | 11,152 |
| Fluorouracil | warnings (topical label) | 6,990 |
| Sulfasalazine | precautions | 6,536 |
| Semaglutide | warnings and precautions (oral label) | 6,462 |
| Lenvatinib | warnings and precautions | 4,133 |
| Doxycycline | warnings (intravenous label) | 4,065 |
| Levofloxacin | warnings and precautions (intravenous label) | 2,552 |
| Leucovorin | precautions | 1,800 |
| Sumatriptan | warnings and precautions (nasal label) | 1,217 |
| Moxifloxacin | warnings and precautions (intravenous label) | 1,133 |
| Erythromycin | warnings (intravenous label) | 1,098 |
| Piperacillin and tazobactam | warnings and precautions (intravenous/ | 1,076 |
| Linezolid | warnings and precautions (oral label) | 1,053 |
| Melphalan | warnings and precautions | 1,043 |
| Fludarabine | precautions | 1,030 |
| Minocycline | warnings and precautions (topical label) | 736 |
| Metolazone | precautions | 659 |
| Rivastigmine | warnings and precautions (transdermal label) | 655 |
| Cefuroxime | warnings (intramuscular/ | 582 |
| Cefdinir | precautions | 530 |
| Tobramycin | warnings (intravenous label) | 515 |
| Aflibercept | warnings and precautions (intravenous label) | 472 |
| Amiodarone | warnings and precautions (intravenous label) | 342 |
| Dofetilide | precautions | 322 |
| Abemaciclib | warnings and precautions | none in the top 1,000 |
| Acarbose | precautions | none in the top 1,000 |
| Acetyl l-tyrosine, alanine and 18 other ingredients | precautions | none in the top 1,000 |
| Alanine, arginine and 16 other ingredients | precautions | none in the top 1,000 |
| Alanine, arginine and 17 other ingredients | precautions | none in the top 1,000 |
| Amoxicillin and clarithromycin and lansoprazole | precautions | none in the top 1,000 |
| Ampicillin | warnings (oral label) | none in the top 1,000 |
| Auranofin | precautions | none in the top 1,000 |
| Cabazitaxel | warnings and precautions | none in the top 1,000 |
| Caffeine and ergotamine | precautions | none in the top 1,000 |
| Capivasertib | warnings and precautions | none in the top 1,000 |
| Cosibelimab | warnings and precautions | none in the top 1,000 |
| Desmopressin | precautions | none in the top 1,000 |
| Dextrose, magnesium chloride and 3 other ingredients | precautions | none in the top 1,000 |
| Diatrizoate | precautions | none in the top 1,000 |
| Dicloxacillin | precautions | none in the top 1,000 |
| Dihydroergotamine | precautions | none in the top 1,000 |
| Entacapone | precautions | none in the top 1,000 |
| Ergotamine | precautions | none in the top 1,000 |
| Ethinyl estradiol and norethindrone | precautions | none in the top 1,000 |
| Fluorescein | warnings and precautions (ophthalmic label) | none in the top 1,000 |
| Fosfomycin | warnings and precautions (intravenous label) | none in the top 1,000 |
| Hyaluronidase and ocrelizumab | warnings and precautions | none in the top 1,000 |
| Magnesium chloride, potassium chloride and 5 other ingredients | precautions | none in the top 1,000 |
| Mecamylamine | precautions | none in the top 1,000 |
| Menotropins | warnings and precautions | none in the top 1,000 |
| Meperidine | warnings and precautions (intramuscular/ | none in the top 1,000 |
| Miglitol | precautions | none in the top 1,000 |
| Nalmefene | warnings and precautions (nasal label) | none in the top 1,000 |
| Naloxone | warnings (intramuscular/ | none in the top 1,000 |
| Ofloxacin | warnings (oral label) | none in the top 1,000 |
| Penicillin g | warnings (intramuscular/ | none in the top 1,000 |
| Pilocarpine | precautions | none in the top 1,000 |
| Pimozide | precautions | none in the top 1,000 |
| Procainamide | precautions | none in the top 1,000 |
| Sevabertinib | warnings and precautions | none in the top 1,000 |
| Temsirolimus | warnings and precautions (intravenous label) | none in the top 1,000 |
| Tigecycline | warnings and precautions (intravenous/ | none in the top 1,000 |
| Tolcapone | precautions | none in the top 1,000 |
| Topotecan | warnings and precautions (oral label) | none in the top 1,000 |
| Ziprasidone | warnings and precautions (intramuscular label) | none in the top 1,000 |
| Zolmitriptan | warnings and precautions (nasal label) | none in the top 1,000 |
| Lenalidomide | adverse reactions | 31,468 |
| Omeprazole | adverse reactions | 25,415 |
| Apremilast | adverse reactions | 24,624 |
| Metformin | adverse reactions | 22,968 |
| Furosemide | adverse reactions | 20,618 |
| Gabapentin | adverse reactions | 18,156 |
| Levothyroxine | adverse reactions | 18,033 |
| Lisinopril | adverse reactions | 17,311 |
| Metoprolol | adverse reactions | 15,020 |
| Amlodipine | adverse reactions | 14,641 |
| Treprostinil | adverse reactions | 13,822 |
| Etanercept | adverse reactions | 13,806 |
| Capecitabine | adverse reactions | 13,623 |
| Atorvastatin | adverse reactions | 11,480 |
| Infliximab | adverse reactions | 10,706 |
| Losartan | adverse reactions | 10,446 |
| Nintedanib | adverse reactions | 10,119 |
| Tirzepatide | adverse reactions | 10,006 |
| Tofacitinib | adverse reactions | 9,882 |
| Rituximab | adverse reactions | 9,689 |
| Ondansetron | adverse reactions | 9,490 |
| Cabozantinib | adverse reactions | 9,449 |
| Leflunomide | adverse reactions | 9,444 |
| Alprazolam | adverse reactions | 9,015 |
| Diphenhydramine | adverse reactions | 8,782 |
| Allopurinol | adverse reactions | 8,696 |
| Oxycodone | adverse reactions | 8,620 |
| Hydrochlorothiazide | adverse reactions | 8,590 |
| Dimethyl fumarate | adverse reactions | 8,293 |
| Potassium chloride | adverse reactions | 8,243 |
| Tadalafil | adverse reactions | 8,044 |
| Secukinumab | adverse reactions | 8,007 |
| Spironolactone | adverse reactions | 7,805 |
| Clopidogrel | adverse reactions | 7,600 |
| Celecoxib | adverse reactions | 7,596 |
| Hydroxychloroquine | adverse reactions | 7,365 |
| Bevacizumab | adverse reactions | 7,349 |
| Diclofenac | adverse reactions (oral label) | 7,310 |
| Acyclovir | adverse reactions | 7,285 |
| Insulin glargine | adverse reactions | 7,220 |
| Ramipril | adverse reactions | 7,184 |
| Carvedilol | adverse reactions | 7,145 |
| Atenolol | adverse reactions | 7,093 |
| Escitalopram | adverse reactions | 7,046 |
| Alendronate | adverse reactions | 7,026 |
| Abatacept | adverse reactions | 6,979 |
| Mycophenolate mofetil | adverse reactions | 6,976 |
| Oxaliplatin | adverse reactions | 6,869 |
| Clonazepam | adverse reactions | 6,808 |
| Trastuzumab | adverse reactions | 6,771 |
| Bisoprolol | adverse reactions | 6,639 |
| Fluticasone | adverse reactions (respiratory (inhalation) label) | 6,365 |
| Citalopram | adverse reactions | 6,347 |
| Certolizumab | adverse reactions | 6,244 |
| Carboplatin | adverse reactions | 6,243 |
| Dulaglutide | adverse reactions | 6,090 |
| Palbociclib | adverse reactions | 5,984 |
| Warfarin | adverse reactions | 5,971 |
| Zolpidem | adverse reactions | 5,968 |
| Tacrolimus | adverse reactions | 5,950 |
| Pembrolizumab | adverse reactions | 5,719 |
| Sertraline | adverse reactions | 5,691 |
| Quetiapine | adverse reactions | 5,633 |
| Cyclophosphamide | adverse reactions | 5,488 |
| Azathioprine | adverse reactions | 5,484 |
| Denosumab | adverse reactions | 5,338 |
| Venlafaxine | adverse reactions | 5,301 |
| Docetaxel | adverse reactions | 5,242 |
| Nivolumab | adverse reactions | 5,235 |
| Bortezomib | adverse reactions | 5,183 |
| Selexipag | adverse reactions | 5,173 |
| Paclitaxel | adverse reactions | 5,149 |
| Fluoxetine | adverse reactions | 5,143 |
| Mesalamine | adverse reactions | 4,921 |
| Montelukast | adverse reactions | 4,848 |
| Teriflunomide | adverse reactions | 4,759 |
| Valsartan | adverse reactions | 4,711 |
| Linaclotide | adverse reactions | 4,703 |
| Ustekinumab | adverse reactions | 4,675 |
| Letrozole | adverse reactions | 4,668 |
| Dupilumab | adverse reactions | 4,535 |
| Adalimumab | patient leaflet | 25,849 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most diarrhea reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Diarrhoea”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch