Side effects across medicines
Medicines whose labels list weakness
1,006 medicines have an FDA label that names weakness (asthenia) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of weakness name prednisone (18,324), ergocalciferol (17,233) and furosemide (15,485), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list weakness?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 1,006 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of weakness |
|---|---|---|
| Ciprofloxacin | boxed warning (intravenous label) | 3,518 |
| Levofloxacin | boxed warning (intravenous label) | 1,754 |
| Moxifloxacin | boxed warning (intravenous label) | 629 |
| Valproic acid | boxed warning (intravenous label) | 390 |
| Ofloxacin | boxed warning (oral label) | none in the top 1,000 |
| Furosemide | precautions | 15,485 |
| Hydrochlorothiazide | precautions | 5,742 |
| Diclofenac | precautions (oral label) | 5,070 |
| Fluticasone | warnings and precautions (respiratory (inhalation) label) | 3,729 |
| Levetiracetam | warnings and precautions (intravenous label) | 2,514 |
| Nitroglycerin | warnings and precautions (oral label) | 2,459 |
| Olanzapine | warnings and precautions (intramuscular label) | 2,134 |
| Morphine | warnings and precautions (intravenous label) | 2,015 |
| Hydromorphone | warnings and precautions (intramuscular/ | 1,748 |
| Buprenorphine | warnings (intramuscular/ | 1,461 |
| Prochlorperazine | warnings (intramuscular/ | 1,314 |
| Botulinum toxin type a | warnings and precautions (intradermal/ | 1,265 |
| Acetaminophen and codeine | precautions | 1,043 |
| Acetaminophen and hydrocodone | precautions | 779 |
| Methadone | precautions (intramuscular/ | 632 |
| Acetaminophen and oxycodone | precautions | 611 |
| Metolazone | precautions | 581 |
| Linezolid | warnings and precautions (oral label) | 568 |
| Erythromycin | precautions (intravenous label) | 552 |
| Buprenorphine and naloxone | warnings and precautions (buccal/ | 446 |
| Chlorthalidone | precautions | 441 |
| Hydrochlorothiazide and lisinopril | precautions | 369 |
| Fludarabine | precautions | 363 |
| Haloperidol | warnings (intramuscular label) | 356 |
| Dapsone | warnings and precautions (topical label) | 288 |
| Tobramycin | warnings and precautions (respiratory (inhalation) label) | 288 |
| Timolol | precautions | 279 |
| Buspirone | precautions | 257 |
| Hydrochlorothiazide and triamterene | precautions | 253 |
| Paliperidone | warnings and precautions (intramuscular label) | 234 |
| Rifampin | precautions | 226 |
| Gentamicin | precautions (intramuscular/ | 198 |
| Alprostadil | precautions (intravascular/ | none in the top 1,000 |
| Amiloride and hydrochlorothiazide | precautions | none in the top 1,000 |
| Aminocaproic acid | warnings (intravenous label) | none in the top 1,000 |
| Aspirin and oxycodone | precautions | none in the top 1,000 |
| Atenolol and chlorthalidone | precautions | none in the top 1,000 |
| Benztropine | precautions | none in the top 1,000 |
| Betaxolol | warnings and precautions (ophthalmic label) | none in the top 1,000 |
| Bisoprolol and hydrochlorothiazide | precautions | none in the top 1,000 |
| Blinatumomab | warnings and precautions | none in the top 1,000 |
| Butorphanol | precautions (nasal label) | none in the top 1,000 |
| Captopril and hydrochlorothiazide | precautions | none in the top 1,000 |
| Carteolol | precautions | none in the top 1,000 |
| Chlorothiazide | precautions | none in the top 1,000 |
| Chlorpromazine | warnings (intramuscular label) | none in the top 1,000 |
| Clomipramine | precautions | none in the top 1,000 |
| Dantrolene | warnings and precautions (intravenous label) | none in the top 1,000 |
| Deoxycholic acid | warnings and precautions | none in the top 1,000 |
| Diflunisal | precautions | none in the top 1,000 |
| Dihydroergotamine | precautions | none in the top 1,000 |
| Disulfiram | precautions | none in the top 1,000 |
| Enalapril and hydrochlorothiazide | precautions | none in the top 1,000 |
| Ethacrynic acid | precautions | none in the top 1,000 |
| Etodolac | precautions | none in the top 1,000 |
| Hyaluronidase and ocrelizumab | warnings and precautions | none in the top 1,000 |
| Hydrocodone and ibuprofen | precautions | none in the top 1,000 |
| Inebilizumab | warnings and precautions | none in the top 1,000 |
| Ketorolac | precautions | none in the top 1,000 |
| Levobunolol | precautions | none in the top 1,000 |
| Levorphanol | precautions | none in the top 1,000 |
| Meclofenamate | precautions | none in the top 1,000 |
| Mepivacaine | warnings (submucosal label) | none in the top 1,000 |
| Nabumetone | precautions | none in the top 1,000 |
| Nalbuphine | warnings (intramuscular/ | none in the top 1,000 |
| Nalmefene | warnings and precautions (nasal label) | none in the top 1,000 |
| Naloxone | warnings (intramuscular/ | none in the top 1,000 |
| Nefazodone | precautions | none in the top 1,000 |
| Phenobarbital | warnings and precautions (intravenous label) | none in the top 1,000 |
| Procainamide | precautions | none in the top 1,000 |
| Succinylcholine | warnings and precautions (intramuscular/ | none in the top 1,000 |
| Sulindac | precautions | none in the top 1,000 |
| Taletrectinib adipate | warnings and precautions | none in the top 1,000 |
| Tiagabine | precautions | none in the top 1,000 |
| Tolmetin | precautions | none in the top 1,000 |
| Trastuzumab-strf | warnings and precautions | none in the top 1,000 |
| Vecuronium | precautions | none in the top 1,000 |
| Ziprasidone | warnings and precautions (intramuscular label) | none in the top 1,000 |
| Prednisone | adverse reactions | 18,324 |
| Ergocalciferol | adverse reactions | 17,233 |
| Omeprazole | adverse reactions | 13,949 |
| Levothyroxine | adverse reactions | 12,745 |
| Gabapentin | adverse reactions | 11,951 |
| Pantoprazole | adverse reactions | 11,434 |
| Lisinopril | adverse reactions | 10,951 |
| Lenalidomide | adverse reactions | 10,121 |
| Simvastatin | adverse reactions | 9,240 |
| Albuterol | adverse reactions (oral label) | 8,935 |
| Dexamethasone | adverse reactions | 8,761 |
| Amlodipine | adverse reactions | 8,735 |
| Pregabalin | adverse reactions | 8,172 |
| Lorazepam | adverse reactions | 7,265 |
| Alprazolam | adverse reactions | 6,814 |
| Rituximab | adverse reactions | 6,449 |
| Interferon beta 1a | adverse reactions (intramuscular label) | 6,291 |
| Losartan | adverse reactions | 6,097 |
| Esomeprazole | adverse reactions (intravenous label) | 5,892 |
| Oxycodone | adverse reactions | 5,660 |
| Allopurinol | adverse reactions | 5,626 |
| Carvedilol | adverse reactions | 5,467 |
| Teriparatide | adverse reactions | 5,447 |
| Ramipril | adverse reactions | 5,252 |
| Clonazepam | adverse reactions | 5,074 |
| Potassium chloride | adverse reactions (intravenous label) | 5,072 |
| Alendronate | adverse reactions | 5,053 |
| Leflunomide | adverse reactions | 5,004 |
| Bisoprolol | adverse reactions | 4,854 |
| Quetiapine | adverse reactions | 4,692 |
| Zolpidem | adverse reactions | 4,532 |
| Rivaroxaban | adverse reactions | 4,528 |
| Escitalopram | adverse reactions | 4,457 |
| Methylprednisolone | adverse reactions | 4,395 |
| Treprostinil | adverse reactions | 4,324 |
| Citalopram | adverse reactions | 4,192 |
| Enzalutamide | adverse reactions | 4,171 |
| Denosumab | adverse reactions | 4,085 |
| Hydrocortisone | adverse reactions (oral label) | 4,085 |
| Venlafaxine | adverse reactions | 3,932 |
| Carboplatin | adverse reactions | 3,895 |
| Palbociclib | adverse reactions | 3,797 |
| Digoxin | adverse reactions | 3,650 |
| Ribavirin | adverse reactions | 3,617 |
| Bevacizumab | adverse reactions | 3,577 |
| Fluoxetine | adverse reactions | 3,497 |
| Baclofen | adverse reactions | 3,461 |
| Dalfampridine | adverse reactions | 3,461 |
| Capecitabine | adverse reactions | 3,414 |
| Tadalafil | adverse reactions | 3,385 |
| Montelukast | adverse reactions | 3,348 |
| Rosuvastatin | adverse reactions | 3,306 |
| Diazepam | adverse reactions | 3,240 |
| Peginterferon alfa 2a | adverse reactions | 3,150 |
| Cyclophosphamide | adverse reactions | 3,147 |
| Sildenafil | adverse reactions | 3,051 |
| Prednisolone | adverse reactions | 3,042 |
| Letrozole | adverse reactions | 2,977 |
| Lamotrigine | adverse reactions | 2,957 |
| Sulfamethoxazole and trimethoprim | adverse reactions | 2,955 |
| Fingolimod | adverse reactions | 2,868 |
| Mycophenolate mofetil | adverse reactions | 2,856 |
| Pembrolizumab | adverse reactions | 2,774 |
| Pomalidomide | adverse reactions | 2,684 |
| Sunitinib | adverse reactions | 2,461 |
| Bupropion | adverse reactions | 2,455 |
| Topiramate | adverse reactions | 2,444 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most weakness reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Asthenia”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch