Side effects across medicines
Medicines whose labels list eye irritation
72 medicines have an FDA label that names eye irritation in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of eye irritation name dupilumab (6,639), lifitegrast (2,741) and latanoprost (2,250), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.
Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.
Which medicines' labels list eye irritation?
Ordered by where the label names it, the boxed warning first, then by FAERS reports. A medicine whose own indications name it, because it treats it, is not counted.
| Medicine | Where a label names it | FAERS reports of eye irritation |
|---|---|---|
| Metronidazole | warnings and precautions (topical label) | 85 |
| Belantamab mafodotin | warnings and precautions | 37 |
| Dupilumab | adverse reactions | 6,639 |
| Lifitegrast | adverse reactions | 2,741 |
| Cenegermin | adverse reactions | 1,879 |
| Bimatoprost | adverse reactions | 1,861 |
| Brimonidine and timolol | adverse reactions | 524 |
| Travoprost | adverse reactions (intracameral label) | 487 |
| Timolol | adverse reactions (oral label) | 479 |
| Clonazepam | adverse reactions | 380 |
| Brimonidine and brinzolamide | adverse reactions | 350 |
| Ranibizumab | adverse reactions | 332 |
| Zolpidem | adverse reactions | 317 |
| Aflibercept | adverse reactions | 314 |
| Alcaftadine | adverse reactions | 170 |
| Difluprednate | adverse reactions | 167 |
| Letrozole | adverse reactions | 110 |
| Capecitabine | adverse reactions | 108 |
| Dexlansoprazole | adverse reactions | 108 |
| Latanoprostene bunod | adverse reactions | 100 |
| Lovastatin | adverse reactions | 99 |
| Diltiazem | adverse reactions | 93 |
| Besifloxacin | adverse reactions | 79 |
| Isotretinoin | adverse reactions | 74 |
| Mupirocin | adverse reactions | 73 |
| Clobetasol | adverse reactions | 62 |
| Varenicline | adverse reactions | 59 |
| Faricimab | adverse reactions | 53 |
| Ganciclovir | adverse reactions (ophthalmic label) | 51 |
| Pilocarpine | adverse reactions (ophthalmic label) | 50 |
| Nilotinib | adverse reactions | 43 |
| Gatifloxacin | adverse reactions | 42 |
| Cromolyn | adverse reactions | 33 |
| Bepotastine | adverse reactions | 32 |
| Natamycin | adverse reactions | 25 |
| Iohexol | adverse reactions | 22 |
| Chloroprocaine | adverse reactions (ophthalmic label) | 18 |
| Pegcetacoplan | adverse reactions (intravitreal label) | 13 |
| Almotriptan | adverse reactions | none in the top 1,000 |
| Arsenic trioxide | adverse reactions | none in the top 1,000 |
| Benoxinate and fluorescein | adverse reactions | none in the top 1,000 |
| Brimonidine and carbachol | adverse reactions | none in the top 1,000 |
| Carteolol | adverse reactions | none in the top 1,000 |
| Cefpodoxime | adverse reactions | none in the top 1,000 |
| Cytarabine and daunorubicin | adverse reactions | none in the top 1,000 |
| Daptomycin | adverse reactions | none in the top 1,000 |
| Desflurane | adverse reactions | none in the top 1,000 |
| Estazolam | adverse reactions | none in the top 1,000 |
| Fosinopril | adverse reactions | none in the top 1,000 |
| Fosinopril and hydrochlorothiazide | adverse reactions | none in the top 1,000 |
| Gefitinib | adverse reactions | none in the top 1,000 |
| Ifosfamide | adverse reactions | none in the top 1,000 |
| Ioversol | adverse reactions | none in the top 1,000 |
| Isoflurane | adverse reactions | none in the top 1,000 |
| Ketorolac and phenylephrine | adverse reactions | none in the top 1,000 |
| Lidocaine and tetracaine | adverse reactions | none in the top 1,000 |
| Lutetium lu 177 vipivotide tetraxetan | adverse reactions | none in the top 1,000 |
| Omidenepag isopropyl | adverse reactions | none in the top 1,000 |
| Propafenone | adverse reactions | none in the top 1,000 |
| Quizartinib | adverse reactions | none in the top 1,000 |
| Revakinagene taroretcel-lwey | adverse reactions | none in the top 1,000 |
| Riboflavin 5-phosphate ophthalmic | adverse reactions (ophthalmic label) | none in the top 1,000 |
| Sirolimus | adverse reactions (topical label) | none in the top 1,000 |
| Tetracaine | adverse reactions | none in the top 1,000 |
| Tisotumab vedotin | adverse reactions | none in the top 1,000 |
| Voretigene neparvovec-rzyl | adverse reactions | none in the top 1,000 |
| Triamcinolone | trial table | 193 |
| Latanoprost | patient leaflet | 2,250 |
| Lidocaine | patient leaflet | 130 |
| Desoximetasone | patient leaflet | 35 |
| Datopotamab deruxtecan | patient leaflet | none in the top 1,000 |
| Ivermectin | Drug Facts: stop use | 25 |
Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026
Which of them have the most eye irritation reports in FAERS?
Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Eye Irritation”
What next?
- Side effects across medicines
- every reaction on PlainMeds
- Report a side effect to the FDA
- MedWatch