Side effects across medicines

Medicines whose labels list swelling of the legs

437 medicines have an FDA label that names swelling of the legs (peripheral edema) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of swelling of the legs name adalimumab (5,699), pregabalin (5,400) and methotrexate (5,142), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list swelling of the legs?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 151 of the 437 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of swelling of the legs
Nifedipine	precautions	871
Felodipine	precautions	240
Ketoconazole	precautions (oral label)	170
Amoxicillin and clarithromycin and lansoprazole	precautions	none in the top 1,000
Rotigotine	warnings and precautions	none in the top 1,000
Adalimumab	adverse reactions	5,699
Pregabalin	adverse reactions	5,400
Omeprazole	adverse reactions	5,096
Amlodipine	adverse reactions	4,542
Metoprolol	adverse reactions	4,227
Ambrisentan	adverse reactions	4,197
Gabapentin	adverse reactions	4,085
Lenalidomide	adverse reactions	3,259
Alendronate	adverse reactions	2,920
Sildenafil	adverse reactions	2,736
Quetiapine	adverse reactions	2,419
Carvedilol	adverse reactions	2,418
Celecoxib	adverse reactions	2,336
Alprazolam	adverse reactions	2,291
Tadalafil	adverse reactions	2,244
Rituximab	adverse reactions	2,215
Insulin glargine	adverse reactions	2,113
Oxycodone	adverse reactions	2,054
Tocilizumab	adverse reactions	1,921
Riociguat	adverse reactions	1,790
Tofacitinib	adverse reactions	1,601
Mycophenolate mofetil	adverse reactions	1,600
Certolizumab	adverse reactions	1,319
Morphine	adverse reactions	1,152
Risedronate	adverse reactions	1,145
Acyclovir	adverse reactions	1,122
Olanzapine	adverse reactions	1,056
Insulin lispro	adverse reactions	1,043
Sitagliptin	adverse reactions	1,034
Mirtazapine	adverse reactions	1,023
Bortezomib	adverse reactions	1,022
Pioglitazone	adverse reactions	1,009
Adalimumab-aaty	adverse reactions	1,002
Adalimumab-fkjp	adverse reactions	1,000
Denosumab	adverse reactions	995
Everolimus	adverse reactions	973
Bupropion	adverse reactions	972
Omalizumab	adverse reactions	928
Bevacizumab	adverse reactions	926
Tacrolimus	adverse reactions	907
Hydromorphone	adverse reactions	879
Enoxaparin	adverse reactions	870
Natalizumab	adverse reactions	858
Budesonide	adverse reactions (oral label)	839
Lamotrigine	adverse reactions	812
Letrozole	adverse reactions	796
Fentanyl	adverse reactions (transdermal label)	794
Risperidone	adverse reactions	782
Baclofen	adverse reactions (intrathecal label)	759
Pimavanserin	adverse reactions	755
Darbepoetin alfa	adverse reactions	747
Ibrutinib	adverse reactions	736
Gemcitabine	adverse reactions	732
Octreotide	adverse reactions (oral label)	719
Insulin aspart	adverse reactions	695
Estrogens conjugated	adverse reactions	653
Trastuzumab	adverse reactions	652
Docetaxel	adverse reactions	642
Pomalidomide	adverse reactions	633
Vancomycin	adverse reactions (oral label)	605
Imatinib	adverse reactions	593
Nivolumab	adverse reactions	589
Thalidomide	adverse reactions	588
Finasteride	adverse reactions	585
Insulin human	adverse reactions	545
Abiraterone	adverse reactions	534
Divalproex	adverse reactions	526
Enzalutamide	adverse reactions	511
Anastrozole	adverse reactions	509
Leuprolide	adverse reactions	506
Nebivolol	adverse reactions	502
Aprepitant	adverse reactions	500
Oxaliplatin	adverse reactions	498
Buprenorphine	adverse reactions (transdermal label)	469
Rabeprazole	adverse reactions	459
Varenicline	adverse reactions	451
Sunitinib	adverse reactions	448
Crizotinib	adverse reactions	445
Eculizumab	adverse reactions	417
Moxifloxacin	adverse reactions (intravenous label)	411
Indapamide	adverse reactions	403
Ribociclib	adverse reactions	399
Carbidopa and levodopa	adverse reactions (enteral label)	392
Fulvestrant	adverse reactions	388
Filgrastim	adverse reactions	384
Exemestane	adverse reactions	377
Amlodipine and valsartan	adverse reactions	353
Mycophenolic acid	adverse reactions	343
Pramipexole	adverse reactions	335
Telmisartan	adverse reactions	313
Raloxifene	adverse reactions	312
Nilotinib	adverse reactions	298
Prochlorperazine	adverse reactions	287
Buprenorphine and naloxone	adverse reactions	285
Paroxetine	adverse reactions	285
Pertuzumab	adverse reactions	257
Lenvatinib	adverse reactions	256
Lorlatinib	adverse reactions	253
Aliskiren	adverse reactions	249
Ixazomib	adverse reactions	249
Iron sucrose	adverse reactions	248
Voriconazole	adverse reactions	247
Capmatinib	adverse reactions	245
Azacitidine	adverse reactions	236
Hydrocodone	adverse reactions	229
Ropinirole	adverse reactions	219
Testosterone	adverse reactions (subcutaneous label)	218
Trametinib	adverse reactions	216
Carfilzomib	adverse reactions	214
Rifaximin	adverse reactions	214
Ipilimumab	adverse reactions	213
Sodium oxybate	adverse reactions	213
Teduglutide	adverse reactions	213
Bicalutamide	adverse reactions	208
Melphalan	adverse reactions	208
Upadacitinib	adverse reactions	206
Valganciclovir	adverse reactions	206
Insulin degludec	adverse reactions	203
Itraconazole	adverse reactions	202
Mifepristone	adverse reactions	202
Eszopiclone	adverse reactions	199
Niacin	adverse reactions	188
Ritonavir	adverse reactions	185
Amantadine	adverse reactions	183
Glatiramer	adverse reactions	182
Interferon beta 1b	adverse reactions	182
Pazopanib	adverse reactions	182
Dabrafenib	adverse reactions	180
Tolterodine	adverse reactions	180
Valproic acid	adverse reactions	178
Metformin and sitagliptin	adverse reactions	175
Alendronate and cholecalciferol	adverse reactions	170
Meropenem	adverse reactions	166
Paricalcitol	adverse reactions	159
Somatropin	adverse reactions	158
Progesterone	adverse reactions (vaginal label)	154
Insulin glulisine	adverse reactions	141
Romiplostim	adverse reactions	140
Terazosin	adverse reactions	140
Lubiprostone	adverse reactions	135
Sodium ferric gluconate complex	adverse reactions	135
Hydrochlorothiazide and lisinopril	adverse reactions	133
Temozolomide	adverse reactions	133
Alemtuzumab	adverse reactions	132
Asenapine	adverse reactions	131
Methotrexate	patient leaflet	5,142

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most swelling of the legs reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Oedema Peripheral”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch