HIGH-VOLUME · HOSP-HEAVY
methylprednisolone Side Effects
methylprednisolone (also sold as Medrol) is HIGH-VOLUME in this FAERS book #52 of 524 by FAERS report count. Signature opener: HOSP-HEAVY - 41.0% mention hospitalization (53,959 reports).
Data updated 2026-05-15
- 131,747
- FAERS reports
FAERS voluntary reports, 2000 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
methylprednisolone: 41.0% mention hospitalization (53,959 reports). Death stamp DEATH-HEAVY; volume band HIGH-VOLUME #52 of 524 by FAERS report count.
High-report extract for methylprednisolone (Medrol): 131,747 FAERS rows (2000-2025). Top named reactions: FATIGUE, PAIN, NAUSEA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2000–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
FATIGUE leads 7,793 of 131,747 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (34,211 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (21,966 reports, 16.7%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 2,735 |
| PNEUMONIA | 2,287 |
| RESPIRATORY FAILURE | 1,624 |
| CONDITION AGGRAVATED | 1,600 |
| SEPSIS | 1,540 |
| DIARRHOEA | 1,464 |
| MULTIPLE ORGAN DYSFUNCTION SYNDROME | 1,459 |
| PYREXIA | 1,449 |
| PAIN | 1,440 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 1,422 |
| RASH | 1,398 |
| HYPERTENSION | 1,362 |
| SEPTIC SHOCK | 1,324 |
| DYSPNOEA | 1,318 |
| INFUSION RELATED REACTION | 1,302 |
| NAUSEA | 1,245 |
| FATIGUE | 1,234 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (53,959, 41.0% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| PYREXIA | 4,215 |
| PNEUMONIA | 4,210 |
| NAUSEA | 3,636 |
| DYSPNOEA | 3,531 |
| DIARRHOEA | 3,301 |
| FATIGUE | 3,246 |
| PAIN | 3,127 |
| HEADACHE | 3,015 |
| CONDITION AGGRAVATED | 3,005 |
| VOMITING | 2,890 |
| ARTHRALGIA | 2,751 |
| ASTHENIA | 2,507 |
| RASH | 2,328 |
| MALAISE | 2,324 |
| HYPERTENSION | 2,305 |
| INFUSION RELATED REACTION | 2,288 |
| RHEUMATOID ARTHRITIS | 1,984 |
How to read methylprednisolone FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 131,747 voluntary reports linked to methylprednisolone (Medrol), 2000-2025. Death is listed on 21,966 (16.7%). Hospitalization appears on 53,959 (41.0%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; HOSP-HEAVY is the page opener, not a per-patient risk.
Read with methylprednisolone
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 131,653 FAERS cases (Δ 94 lighter vs methylprednisolone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 130,943 FAERS cases (Δ 804 lighter vs methylprednisolone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 130,791 FAERS cases (Δ 956 lighter vs methylprednisolone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 133,227 FAERS cases (Δ 1,480 heavier vs methylprednisolone); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 45.4 pp vs methylprednisolone's DEATH-HEAVY): CASELOAD · HOSP-MID.
methylprednisolone stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.