HIGH-VOLUME · FEMALE-LED
adapalene Side Effects
adapalene (also sold as Differin) is HIGH-VOLUME in this FAERS book #36 of 524 by FAERS report count. Signature opener: FEMALE-LED - 78% of sex-coded reports are female (122,669 F / 34,451 M).
Data updated 2026-05-15
- 178,147
- FAERS reports
FAERS voluntary reports, 2004 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
adapalene reporting skew - 78% of sex-coded reports are female (122,669 F / 34,451 M). Volume band HIGH-VOLUME #36 of 524 by FAERS report count; caseload MEGA-CASE.
High-report extract for adapalene (Differin): 178,147 FAERS rows (2004-2025). Top named reactions: DRY SKIN, SKIN BURNING SENSATION, ACNE. Outcome stamps DEATH-RARE · HOSP-LIGHT · FEMALE-LED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2004–2025). Stamps MEGA-CASE · DEATH-RARE · HOSP-LIGHT · FEMALE-LED.
DRY SKIN leads 44,990 of 178,147 reports
FEMALE-LED reporters · age peak 18-44
Female-led reporters (78% of sex-coded rows)
Age peak 18-44 (43,798 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death is rare in this extract (32 / 178,147). Co-reported reactions in that thin subset:
| Reaction | Reports |
|---|---|
| DEATH | 12 |
| PAIN | 5 |
| DYSPNOEA | 4 |
| EMOTIONAL DISTRESS | 4 |
| WEIGHT DECREASED | 4 |
| ANXIETY | 3 |
| ASTHMA | 3 |
| BONE DENSITY DECREASED | 3 |
| COMPLETED SUICIDE | 3 |
| CONSTIPATION | 3 |
| DEPRESSION | 3 |
| HAEMATEMESIS | 3 |
| MALAISE | 3 |
| OSTEOPENIA | 3 |
| PLATELET COUNT DECREASED | 3 |
| RASH | 3 |
| AMYLASE DECREASED | 2 |
| ANAEMIA | 2 |
Reactions in Hospitalization Reports
Hospitalization is lighter here (358). Reactions in that subset:
| Reaction | Reports |
|---|---|
| DYSPNOEA | 41 |
| PAIN | 41 |
| ANXIETY | 39 |
| HYPERSENSITIVITY | 32 |
| PULMONARY EMBOLISM | 29 |
| FATIGUE | 27 |
| DEPRESSION | 26 |
| NAUSEA | 24 |
| INJURY | 23 |
| DIZZINESS | 22 |
| EMOTIONAL DISTRESS | 22 |
| DEEP VEIN THROMBOSIS | 21 |
| HEADACHE | 21 |
| RASH | 21 |
| MALAISE | 19 |
| ABDOMINAL PAIN | 18 |
| ERYTHEMA | 18 |
| PYREXIA | 18 |
| DRY SKIN | 17 |
| PARAESTHESIA | 17 |
How to read adapalene FAERS figures (MEGA-CASE · DEATH-RARE · HOSP-LIGHT)
FAERS holds 178,147 voluntary reports linked to adapalene (Differin), 2004-2025. Death is listed on 32 (0.0%). Hospitalization appears on 358 (0.2%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; FEMALE-LED is the page opener, not a per-patient risk.
Read with adapalene
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-RARE · HOSP-LIGHT stamps.
ABS(total_reports) peer at 180,422 FAERS cases (Δ 2,275 heavier vs adapalene); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-RARE · HOSP-LIGHT · FEMALE-LED.
ABS(total_reports) peer at 174,469 FAERS cases (Δ 3,678 lighter vs adapalene); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-RARE · HOSP-LIGHT · FEMALE-LED.
ABS(total_reports) peer at 181,998 FAERS cases (Δ 3,851 heavier vs adapalene); DEATH-MARKED · HOSP-MID · FEMALE-LED vs this page's MEGA-CASE · DEATH-RARE · HOSP-LIGHT · FEMALE-LED.
ABS(total_reports) peer at 173,227 FAERS cases (Δ 4,920 lighter vs adapalene); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-RARE · HOSP-LIGHT · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 62.1 pp vs adapalene's DEATH-RARE): CASELOAD · HOSP-MID.
adapalene sits in MEGA-CASE; high report volume tracks exposure and reporting culture more than per-patient risk. Methodology states the de-dup rules.