Side effects across medicines

Medicines whose labels list fatigue

920 medicines have an FDA label that names fatigue in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of fatigue name methotrexate (32,749), lenalidomide (26,783) and omeprazole (26,030), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list fatigue?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 920 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of fatigue
Methotrexate	precautions (intra-arterial/intramuscular/intrathecal/intravenous label)	32,749
Furosemide	precautions	21,054
Hydrochlorothiazide	precautions	10,329
Fluticasone	warnings and precautions (respiratory (inhalation) label)	8,570
Levetiracetam	warnings and precautions (intravenous label)	5,589
Morphine	warnings and precautions (intravenous label)	4,011
Hydromorphone	warnings and precautions (intramuscular/intravenous/subcutaneous label)	3,620
Clonidine	precautions	3,008
Acetaminophen and codeine	precautions	1,995
Buprenorphine	warnings (intramuscular/intravenous label)	1,983
Acetaminophen and oxycodone	precautions	1,622
Acetaminophen and hydrocodone	precautions	1,567
Lovastatin	precautions	1,537
Methadone	precautions (intramuscular/intravenous/subcutaneous label)	1,327
Chlorthalidone	precautions	908
Buprenorphine and naloxone	warnings and precautions (buccal/sublingual label)	782
Hydrochlorothiazide and lisinopril	precautions	672
Metolazone	precautions	662
Zonisamide	precautions	496
Hydrochlorothiazide and triamterene	precautions	400
Acetazolamide	precautions	none in the top 1,000
Amiloride and hydrochlorothiazide	precautions	none in the top 1,000
Aspirin and oxycodone	precautions	none in the top 1,000
Atenolol and chlorthalidone	precautions	none in the top 1,000
Bacillus calmette-guerin substrain tice live antigen	precautions	none in the top 1,000
Benzocaine	warnings (dental/oral/periodontal label)	none in the top 1,000
Bisoprolol and hydrochlorothiazide	precautions	none in the top 1,000
Butorphanol	precautions (nasal label)	none in the top 1,000
Captopril and hydrochlorothiazide	precautions	none in the top 1,000
Chlorothiazide	precautions	none in the top 1,000
Disulfiram	precautions	none in the top 1,000
Enalapril and hydrochlorothiazide	precautions	none in the top 1,000
Hydrocodone and ibuprofen	precautions	none in the top 1,000
Levorphanol	precautions	none in the top 1,000
Mepivacaine	warnings (submucosal label)	none in the top 1,000
Nalbuphine	warnings (intramuscular/intravenous/subconjunctival label)	none in the top 1,000
Viloxazine	warnings and precautions	none in the top 1,000
Vosoritide	warnings and precautions	none in the top 1,000
Lenalidomide	adverse reactions	26,783
Omeprazole	adverse reactions	26,030
Levothyroxine	adverse reactions	25,382
Gabapentin	adverse reactions	25,140
Pantoprazole	adverse reactions	20,773
Lisinopril	adverse reactions	19,911
Natalizumab	adverse reactions	19,583
Rituximab	adverse reactions	17,224
Tofacitinib	adverse reactions	16,848
Infliximab	adverse reactions	16,696
Amlodipine	adverse reactions	16,328
Diphenhydramine	adverse reactions	15,900
Palbociclib	adverse reactions	15,729
Pregabalin	adverse reactions	15,635
Atorvastatin	adverse reactions	14,250
Hydroxychloroquine	adverse reactions	14,220
Lorazepam	adverse reactions	13,819
Certolizumab	adverse reactions	13,664
Losartan	adverse reactions	12,472
Alprazolam	adverse reactions	12,186
Interferon beta 1a	adverse reactions	11,550
Clonazepam	adverse reactions	10,473
Ondansetron	adverse reactions	10,275
Enzalutamide	adverse reactions	10,267
Celecoxib	adverse reactions	10,099
Ribavirin	adverse reactions	9,561
Escitalopram	adverse reactions	9,541
Peginterferon alfa 2a	adverse reactions	9,258
Quetiapine	adverse reactions	9,207
Carvedilol	adverse reactions	8,913
Montelukast	adverse reactions	8,688
Ramipril	adverse reactions	8,164
Denosumab	adverse reactions	7,745
Cabozantinib	adverse reactions	7,696
Sertraline	adverse reactions	7,662
Atenolol	adverse reactions	7,657
Pomalidomide	adverse reactions	7,499
Letrozole	adverse reactions	7,410
Bisoprolol	adverse reactions	7,142
Ustekinumab	adverse reactions	6,838
Rivaroxaban	adverse reactions	6,729
Capecitabine	adverse reactions	6,477
Bevacizumab	adverse reactions	6,454
Vedolizumab	adverse reactions	6,307
Baclofen	adverse reactions	6,276
Apremilast	adverse reactions	6,225
Lamotrigine	adverse reactions	6,174
Ruxolitinib	adverse reactions	6,114
Omalizumab	adverse reactions	6,113
Tadalafil	adverse reactions	6,092
Eculizumab	adverse reactions	5,890
Diazepam	adverse reactions	5,833
Relugolix	adverse reactions	5,754
Valsartan	adverse reactions	5,634
Ofatumumab	adverse reactions	5,534
Topiramate	adverse reactions	5,424
Sulfamethoxazole and trimethoprim	adverse reactions	5,408
Niraparib	adverse reactions	5,233
Pembrolizumab	adverse reactions	5,112
Leuprolide	adverse reactions	5,099
Duloxetine	adverse reactions	5,059
Ezetimibe	adverse reactions	4,980
Ibrutinib	adverse reactions	4,752
Estradiol	adverse reactions (topical label)	4,682
Bortezomib	adverse reactions	4,550
Trastuzumab	adverse reactions	4,370
Valacyclovir	adverse reactions	4,317
Aripiprazole	adverse reactions	4,306
Cyclophosphamide	adverse reactions	4,226
Sunitinib	adverse reactions	4,192
Fulvestrant	adverse reactions	4,182
Nivolumab	adverse reactions	4,174
Ledipasvir and sofosbuvir	adverse reactions	4,131
Evolocumab	adverse reactions	4,059
Cyclobenzaprine	adverse reactions	4,026
Fluticasone and salmeterol	adverse reactions	3,936
Propranolol	adverse reactions	3,912
Mesalamine	adverse reactions	3,839
Ribociclib	adverse reactions	3,813
Pirfenidone	adverse reactions	3,806
Everolimus	adverse reactions	3,775
Budesonide	adverse reactions	3,619
Olanzapine	adverse reactions	3,605
Fentanyl	adverse reactions (transdermal label)	3,577
Sarilumab	adverse reactions	3,555
Metoclopramide	adverse reactions	3,531
Octreotide	adverse reactions	3,531
Cyclosporine	adverse reactions	3,489
Anastrozole	adverse reactions	3,444
Abaloparatide	adverse reactions	3,419
Lenvatinib	adverse reactions	3,333
Fluconazole	adverse reactions	3,264
Methylphenidate	adverse reactions	3,179
Varenicline	adverse reactions	3,175
Risankizumab	adverse reactions	3,093
Mepolizumab	adverse reactions	3,078
Semaglutide	adverse reactions	3,063
Risperidone	adverse reactions	3,021
Nintedanib	adverse reactions	2,961
Azithromycin	adverse reactions	2,866
Metronidazole	adverse reactions (vaginal label)	2,839
Temazepam	adverse reactions	2,832
Oxaliplatin	adverse reactions	2,822
Zoledronic acid	adverse reactions	2,797
Upadacitinib	adverse reactions	2,692
Abiraterone	adverse reactions	2,676
Venetoclax	adverse reactions	2,637
Sofosbuvir and velpatasvir	adverse reactions	2,624
Glecaprevir and pibrentasvir	adverse reactions	2,565
Rucaparib camsylate	adverse reactions	2,551
Irbesartan	adverse reactions	2,546
Carbamazepine	adverse reactions	2,523

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most fatigue reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Fatigue”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch