Side effects across medicines

Medicines whose labels list weight loss

365 medicines have an FDA label that names weight loss in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of weight loss name adalimumab (12,898), ergocalciferol (12,632) and methotrexate (11,257), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list weight loss?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 152 of the 365 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of weight loss
Octreotide	warnings and precautions (oral label)	2,280
Amphetamine and dextroamphetamine	precautions	1,166
Rivastigmine	warnings and precautions (transdermal label)	593
Gemfibrozil	precautions	428
Metolazone	precautions	359
Rifampin	precautions	262
Melphalan	precautions	178
Dextroamphetamine	precautions	161
Amphetamine	precautions	none in the top 1,000
Doxercalciferol	warnings and precautions (oral label)	none in the top 1,000
Entacapone	precautions	none in the top 1,000
Ethacrynic acid	warnings (intravenous label)	none in the top 1,000
Paricalcitol	warnings and precautions (intravenous label)	none in the top 1,000
Pasireotide	warnings and precautions	none in the top 1,000
Tiagabine	precautions	none in the top 1,000
Ergocalciferol	adverse reactions	12,632
Levothyroxine	adverse reactions	9,650
Infliximab	adverse reactions	7,434
Amlodipine	adverse reactions	6,154
Alprazolam	adverse reactions	5,450
Apremilast	adverse reactions	5,046
Lenalidomide	adverse reactions	4,996
Clonazepam	adverse reactions	4,774
Carvedilol	adverse reactions	3,501
Hydroxychloroquine	adverse reactions	3,355
Escitalopram	adverse reactions	3,343
Citalopram	adverse reactions	3,214
Zolpidem	adverse reactions	3,077
Nintedanib	adverse reactions	3,040
Cabozantinib	adverse reactions	3,038
Topiramate	adverse reactions	2,983
Venlafaxine	adverse reactions	2,951
Sertraline	adverse reactions	2,921
Sodium oxybate	adverse reactions	2,783
Mycophenolate mofetil	adverse reactions	2,760
Fluoxetine	adverse reactions	2,743
Peginterferon alfa 2a	adverse reactions	2,659
Ribavirin	adverse reactions	2,588
Bupropion	adverse reactions	2,561
Mirtazapine	adverse reactions	2,244
Pirfenidone	adverse reactions	2,231
Levetiracetam	adverse reactions	2,073
Capecitabine	adverse reactions	2,043
Lamotrigine	adverse reactions	2,013
Palbociclib	adverse reactions	1,982
Bevacizumab	adverse reactions	1,967
Everolimus	adverse reactions	1,920
Nivolumab	adverse reactions	1,847
Pembrolizumab	adverse reactions	1,817
Baclofen	adverse reactions (intrathecal label)	1,809
Fentanyl	adverse reactions (transdermal label)	1,801
Enzalutamide	adverse reactions	1,784
Letrozole	adverse reactions	1,683
Sunitinib	adverse reactions	1,588
Duloxetine	adverse reactions	1,497
Cyclosporine	adverse reactions	1,490
Natalizumab	adverse reactions	1,438
Lenvatinib	adverse reactions	1,431
Risperidone	adverse reactions	1,418
Carbidopa and levodopa	adverse reactions	1,413
Insulin human	adverse reactions (respiratory (inhalation) label)	1,304
Ibrutinib	adverse reactions	1,289
Trastuzumab	adverse reactions	1,140
Divalproex	adverse reactions	1,082
Fulvestrant	adverse reactions	1,057
Clozapine	adverse reactions	989
Oxaliplatin	adverse reactions	976
Nifedipine	adverse reactions	963
Tramadol	adverse reactions	941
Anastrozole	adverse reactions	925
Sorafenib	adverse reactions	917
Pazopanib	adverse reactions	882
Cannabidiol	adverse reactions	864
Zoledronic acid	adverse reactions	852
Lomitapide	adverse reactions	842
Paroxetine	adverse reactions	837
Axitinib	adverse reactions	802
Donepezil	adverse reactions	797
Atomoxetine	adverse reactions	746
Vismodegib	adverse reactions	738
Cetuximab	adverse reactions	685
Ipilimumab	adverse reactions	669
Pomalidomide	adverse reactions	663
Selinexor	adverse reactions	648
Regorafenib	adverse reactions	636
Nilotinib	adverse reactions	631
Trofinetide	adverse reactions	579
Aprepitant	adverse reactions	574
Oxcarbazepine	adverse reactions	570
Buprenorphine	adverse reactions (transdermal label)	556
Etonogestrel	adverse reactions	544
Epoetin	adverse reactions	542
Calcitriol	adverse reactions	516
Cholestyramine	adverse reactions	516
Glatiramer	adverse reactions	481
Lithium	adverse reactions	469
Roflumilast	adverse reactions	447
Eszopiclone	adverse reactions	433
Amikacin	adverse reactions (respiratory (inhalation) label)	431
Fenfluramine	adverse reactions	431
Ropinirole	adverse reactions	426
Indapamide	adverse reactions	413
Pramipexole	adverse reactions	409
Progesterone	adverse reactions	404
Calcium oxybate, magnesium oxybate, potassium oxybate and sodium oxybate	adverse reactions	403
Naltrexone	adverse reactions	403
Lanreotide	adverse reactions	398
Bicalutamide	adverse reactions	381
Medroxyprogesterone	adverse reactions (subcutaneous label)	377
Trazodone	adverse reactions	371
Valproic acid	adverse reactions	362
Isotretinoin	adverse reactions	361
Emtricitabine and tenofovir disoproxil	adverse reactions	351
Thalidomide	adverse reactions	337
Brentuximab vedotin	adverse reactions	318
Buspirone	adverse reactions	310
Rasagiline	adverse reactions	308
Tenofovir disoproxil	adverse reactions	304
Liothyronine	adverse reactions	298
Rucaparib camsylate	adverse reactions	296
Haloperidol	adverse reactions (intramuscular label)	295
Interferon beta 1b	adverse reactions	290
Lopinavir and ritonavir	adverse reactions	281
Erlotinib	adverse reactions	278
Valganciclovir	adverse reactions	276
Ertapenem	adverse reactions	273
Ketoprofen	adverse reactions	265
Hydrochlorothiazide and lisinopril	adverse reactions	259
Trastuzumab deruxtecan	adverse reactions	257
Captopril	adverse reactions	252
Apalutamide	adverse reactions	245
Zonisamide	adverse reactions	244
Vincristine	adverse reactions	243
Panitumumab	adverse reactions	240
Febuxostat	adverse reactions	225
Terbinafine	adverse reactions	222
Azacitidine	adverse reactions	219
Irinotecan	adverse reactions	208
Afatinib	adverse reactions	207
Enfortumab vedotin	adverse reactions	201
Bendamustine	adverse reactions	199
Timolol	adverse reactions (oral label)	196
Crizotinib	adverse reactions	195
Zidovudine	adverse reactions	183
Clofazimine	adverse reactions	179
Talquetamab	adverse reactions	174
Tucatinib	adverse reactions	166
Ripretinib	adverse reactions	165
Abemaciclib	adverse reactions	none in the top 1,000
Abiraterone and niraparib	adverse reactions	none in the top 1,000
Adalimumab	patient leaflet	12,898
Methotrexate	patient leaflet	11,257

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most weight loss reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Weight Decreased”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch