Prescription medicine
Sertraline Brand names: Zoloft
Sertraline (Zoloft) is a prescription medicine with an FDA approval on record since 1991. FDA's NDC Directory lists it from 47 generic labelers, and pharmacies paid $0.0507 per sertraline HCl 100 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
- Boxed warning
Check it at the source: the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC); the NDA 19839 record on Drugs@FDA; every sertraline label on DailyMed.
Highlights of the record
FDA label of August 8, 2023; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
SUICIDAL THOUGHTS AND BEHAVIORS.
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors [See Warnings and Precautions (5.1) ]. WARNING: SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed warning.
Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients ( 5.1 )
Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors
Used for
From the label: indications and usageZOLOFT is indicated for the treatment of the following [See Clinical Studies (14) ]:
Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Posttraumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD) ZOLOFT is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of ( 1 ):
Major depressive disorder (MDD)
Forms and strengths
- 25 mg
- 50 mg
- 100 mg
- 150 mg
- 200 mg
- 20 mg/ml
Film-coated tablet; tablet; capsule; solution (concentrate); solution.
On the market
- Earliest approval on file
- December 30, 1991 Zoloft, Viatris; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 34 first June 30, 2006; 21 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 51 of which 47 under generic applications, 2 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.0507 per tablet Sertraline HCl 100 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 3 since 2013 0 Class I among all firms' recalls; latest November 5, 2025; 1 more by firms not listed as its makers
- FAERS reports
- 218,311 through July 30, 2026
What is sertraline used for?
From the label: indications and usageZOLOFT is indicated for the treatment of the following [See Clinical Studies (14) ]:
Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Posttraumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD) ZOLOFT is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of ( 1 ):
Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Posttraumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD)
Conditions named in the indications of sertraline's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Serotonin Reuptake Inhibitor.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What does the patient leaflet for sertraline say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about ZOLOFT?ZOLOFT and other antidepressant medicines may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms, or call 911 if there is an emergency. 1. Suicidal thoughts or actions: • ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. • Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. • Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. o Pay particular attention to such changes when ZOLOFT is started or when the dose is changed. o Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you: o attempts to commit suicide o acting aggressive or violent o new or worse depression o feeling agitated, restless, angry or irritable o an increase in activity or talking more than what is normal for you o acting on dangerous impulses o thoughts about suicide or dying o new or worse anxiety or panic attacks o trouble sleeping o other unusual changes in behavior or mood 2. Serotonin Syndrome. […]
From the patient leaflet: What should I avoid while taking ZOLOFT?ZOLOFT can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how ZOLOFT affects you. Do not drink alcohol while you take ZOLOFT.
From the patient leaflet: How should I store ZOLOFT?Store ZOLOFT at room temperature, 68°F to 77°F (20°C to 25°C). • Keep ZOLOFT bottle closed tightly. Keep ZOLOFT and all medicines out of the reach of children.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
Is there a generic for sertraline (Zoloft)?
The FDA approved the first generic sertraline on June 30, 2006. 34 generic applications are approved; 21 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale. Drugs@FDA also holds 1 tentative approval: the FDA found the generic approvable, but patents or exclusivity keep it from final approval for now.
FDA's NDC Directory lists sertraline from 47 labelers under a generic (ANDA) application and from 2 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1991 earliest approval on file
- 2006 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for sertraline (Zoloft)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.0507 per Sertraline HCl 100 mg tablet, down 3% from $0.0523 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Sertraline HCl 50 mg tablet (generic)
- Zoloft 50 mg tablet (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Sertraline 150 mg capsule | Generic | $1.25 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $37.52 | -76% |
| Sertraline 20 mg/mL oral conc | Generic | $0.365 per mL | n/a | -20% |
| Sertraline 200 mg capsule | Generic | $1.74 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $52.08 | -66% |
| Sertraline HCl 100 mg tablet | Generic | $0.0507 per tablet | $1.52 | -3% |
| Sertraline HCl 25 mg tablet | Generic | $0.0288 per tablet | $0.865 | -13% |
| Sertraline HCl 50 mg tablet | Generic | $0.0348 per tablet | $1.04 | -2% |
| Zoloft 100 mg tablet | Brand | $14.94 per tablet many times the lowest per-tablet cost; NADAC records the price, not why | $448.30 | +5% |
| Zoloft 25 mg tablet | Brand | $15.17 per tablet many times the lowest per-tablet cost; NADAC records the price, not why | $455.13 | +7% |
| Zoloft 50 mg tablet | Brand | $14.91 per tablet many times the lowest per-tablet cost; NADAC records the price, not why | $447.22 | +5% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has sertraline been recalled?
The FDA's Enforcement Report lists 4 recalls naming sertraline since 2013: 0 Class I (the most serious), 4 Class II, 0 Class III; 2 still ongoing. 1 of them is by a firm that FDA's NDC Directory does not list as a maker of sertraline and that holds no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| November 5, 2025 | Class II | Lupin Pharmaceuticals Inc. | Defective container - seal not adhering to bottles |
| December 11, 2023 | Class II | Legacy Pharmaceutical Packaging LLC | CGMP Deviations: Inadequate line clearance which may result in a potential comingling of product. |
| November 5, 2013 | Class II | Greenstone LLC | Labeling: Incorrect or Missing Lot No. and/or Exp Date: Expiration date incorrectly reflects a 36 month shelf life, instead of the 24 month shelf life |
| July 2, 2013 | Class II | Aidapak Services, LLC not a listed maker | Labeling: Label Mixup; SERTRALINE HCL Tablet, 50 mg may be potentially mislabeled as NORTRIPTYLINE HCL, Capsule, 10 mg, NDC 00093081001, Pedigree: AD70585_4 … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the sertraline label say about other medicines?
The sertraline label names 48 other medicines in its interaction, contraindication or warning sections. The labels of 41 other medicines name sertraline. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Amiodarone | drug interactions | Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus). |
| Aspirin | drug interactions | Drugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. … warfarin, carefully monitor the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin |
| Atenolol | drug interactions | Additionally, no dosage adjustment is required for diazepam, lithium, atenolol, tolbutamide, digoxin, and drugs metabolized by CYP3A4, when ZOLOFT is administered concomitantly [See Clinical Pharmacology (12.3) ]. |
| Atomoxetine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … may be needed if ZOLOFT is discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Buspirone | drug interactions | Clinical Impact: The concomitant use of serotonergic drugs with ZOLOFT increases the risk of serotonin syndrome. … SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. John’s Wort. |
| Chlorpromazine | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
| Cimetidine | drug interactions | Interactions with ZOLOFT Based on pharmacokinetic studies, no dosage adjustment of ZOLOFT is necessary when used in combination with cimetidine. |
| Clopidogrel | drug interactions | Drugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. … carefully monitor the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin |
| Desipramine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … if ZOLOFT is discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Dextromethorphan | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Diazepam | drug interactions | Additionally, no dosage adjustment is required for diazepam, lithium, atenolol, tolbutamide, digoxin, and drugs metabolized by CYP3A4, when ZOLOFT is administered concomitantly [See Clinical Pharmacology (12.3) ]. |
| Digoxin | drug interactions | Additionally, no dosage adjustment is required for diazepam, lithium, atenolol, tolbutamide, digoxin, and drugs metabolized by CYP3A4, when ZOLOFT is administered concomitantly [See Clinical Pharmacology (12.3) ]. |
| Disulfiram | contraindications | ZOLOFT oral solution contains alcohol, and concomitant use of ZOLOFT and disulfiram may result in a disulfiram-alcohol reaction. |
| Droperidol | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
Every other medicine the sertraline label names
| Medicine named | Section | What the label says |
|---|---|---|
| Erythromycin | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
| Fentanyl | warnings and precautions | The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone … |
| Flecainide | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … substrate may be needed if ZOLOFT is discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Fosphenytoin | drug interactions | Clinical Impact: Phenytoin is a narrow therapeutic index drug. ZOLOFT may increase phenytoin concentrations. Intervention: Monitor phenytoin levels when initiating or titrating ZOLOFT. Reduce phenytoin dosage if needed. Examples: phenytoin, fosphenytoin Drugs that Prolong the QTc Interval |
| Gatifloxacin | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
| Heparin | drug interactions | Drugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. … the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin |
| Iloperidone | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
| Isocarboxazid | drug interactions | Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. … intravenous methylene blue [See,, ]. Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue |
| Linezolid | contraindications | CONTRAINDICATIONS ZOLOFT is contraindicated in patients: Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of … |
| Lithium | drug interactions | Clinical Impact: The concomitant use of serotonergic drugs with ZOLOFT increases the risk of serotonin syndrome. … (5.2) ]. Other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. John’s Wort. |
| Mefloquine | drug interactions | Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus). |
| Meperidine | warnings and precautions | The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone … |
| Methadone | drug interactions | Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus). |
| Methylene blue | contraindications | … of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome [See Warnings and Precautions (5.2), Drug Interactions (7.1) ]. |
| Metoprolol | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Moxifloxacin | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
| Nebivolol | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Perphenazine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Phenelzine | drug interactions | Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. … methylene blue [See,, ]. Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue |
| Phenytoin | drug interactions | Phenytoin Clinical Impact: Phenytoin is a narrow therapeutic index drug. ZOLOFT may increase phenytoin concentrations. Intervention: Monitor phenytoin levels when initiating or titrating ZOLOFT. Reduce phenytoin dosage if needed. Examples: phenytoin, fosphenytoin |
| Pimozide | contraindications | Taking pimozide [See Drug Interactions (7.1) ]. |
| Procainamide | drug interactions | Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); |
| Propafenone | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … of a CYP2D6 substrate may be needed if ZOLOFT is discontinued. Examples: propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Quinidine | drug interactions | Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); |
| Selegiline | drug interactions | Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. Intervention: ZOLOFT is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [See,, ]. … |
| Sotalol | drug interactions | Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus). |
| Tacrolimus | drug interactions | Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus). |
| Thioridazine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Tolterodine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Tramadol | warnings and precautions | The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone … |
| Tranylcypromine | drug interactions | Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. Intervention: ZOLOFT is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [See,, ]. … |
| Venlafaxine | drug interactions | Drugs Metabolized by CYP2D6 Clinical Impact: ZOLOFT is a CYP2D6 inhibitor [See ]. The concomitant use of ZOLOFT with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. … dextromethorphan, metoprolol, nebivolol, perphenazine, thioridazine, tolterodine, venlafaxine |
| Warfarin | drug interactions | Protein-bound drugs: Monitor for adverse reactions and reduce dosage of ZOLOFT or other protein-bound drugs (e.g., warfarin) as warranted. |
| Ziprasidone | drug interactions | Specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); |
Other labels that name sertraline
- Almotriptan
- Amitriptyline
- Bupropion
- Carbamazepine
- Clomipramine
- Clonazepam
- Clozapine
- Cobicistat, elvitegravir, emtricitabine and tenofovir alafenamide
- Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil
- Darunavir
- Doxepin
- Efavirenz
- Fluvoxamine
- Gilteritinib
- Imipramine
- Ivacaftor and lumacaftor
- Levothyroxine
- Liothyronine
- Nortriptyline
- Stiripentol
- Trimipramine
- Zolpidem
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What do FAERS reports show for sertraline?
The FDA Adverse Event Reporting System holds 218,311 reports that list sertraline among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 18,962 are coded as a death and 68,336 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as sertraline?
30 other medicines are given the same way (oral) and in the same FDA class as sertraline or labeled mainly for the same use (depression), the same class first. Depression lists all 37 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Fluoxetine | Depression, Anxiety | 59 labelers | $0.0519 per capsule 40 mg capsule | No current entry |
| Paroxetine | Depression, Anxiety | 45 labelers | $0.0611 per tablet 20 mg tablet | No current entry |
| Trazodone | Depression | 38 labelers | $0.0307 per tablet 50 mg tablet | No current entry |
| Escitalopram | Depression, Anxiety | 44 labelers | $0.0632 per tablet 20 mg tablet | No current entry |
| Citalopram | Depression | 35 labelers | $0.026 per tablet 10 mg tablet | No current entry |
| Fluoxetine and olanzapine | Depression | 3 labelers | $3.44 per unit 3-25 mg | No current entry |
| Nefazodone | Depression | 2 labelers | $1.17 per tablet 100 mg tablet | No current entry |
| Bupropion | Depression | 73 labelers | $0.0785 per tablet 150 mg tablet | No current entry |
Every medicine labeled for the same conditions as sertraline
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does sertraline compare with medicines for the same use?
23 side-by-side pages set sertraline beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to sertraline
- 30 medicines for the same use
- Other serotonin reuptake inhibitors
- the pharmacologic class, with prices and generics
- Sertraline side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other