Side effects across medicines

Medicines whose labels list muscle pain

624 medicines have an FDA label that names muscle pain (myalgia) in its boxed warning, warnings, adverse reactions, trial table, patient leaflet or Drug Facts “stop use” warning (of the labels PlainMeds reads: each medicine's quoted label and up to eight more, by route and wording). Among them, the most FAERS reports of muscle pain name atorvastatin (9,961), simvastatin (8,443) and omeprazole (5,878), through July 30, 2026. A label lists what its studies and reports found, and a report does not show that a medicine caused the event.

Check it at the source: the FDA FAERS public dashboard; FDA labels on DailyMed.

Which medicines' labels list muscle pain?

Ordered by where the label names it, the boxed warning first, then by FAERS reports. The first 150 of the 624 are below; every other one is on its medicine record. A medicine whose own indications name it, because it treats it, is not counted.

Medicine	Where a label names it	FAERS reports of muscle pain
Furosemide	precautions	3,962
Ciprofloxacin	warnings and precautions (intravenous label)	2,891
Hydrochlorothiazide	precautions	2,206
Levofloxacin	warnings and precautions (intravenous label)	1,220
Moxifloxacin	warnings and precautions (intravenous label)	269
Chlorthalidone	precautions	171
Hydrochlorothiazide and lisinopril	precautions	145
Ibandronate	warnings and precautions (intravenous label)	142
Ofloxacin	warnings (oral label)	140
Metolazone	precautions	134
Hydrochlorothiazide and triamterene	precautions	102
Amiloride and hydrochlorothiazide	precautions	none in the top 1,000
Atenolol and chlorthalidone	precautions	none in the top 1,000
Avutometinib and defactinib	warnings and precautions	none in the top 1,000
Bisoprolol and hydrochlorothiazide	precautions	none in the top 1,000
Caffeine and ergotamine	precautions	none in the top 1,000
Captopril and hydrochlorothiazide	precautions	none in the top 1,000
Chlorothiazide	precautions	none in the top 1,000
Dihydroergotamine	warnings (intramuscular/intravenous/subcutaneous label)	none in the top 1,000
Enalapril and hydrochlorothiazide	precautions	none in the top 1,000
Entacapone	precautions	none in the top 1,000
Ergotamine	precautions	none in the top 1,000
Glipizide and metformin	precautions	none in the top 1,000
Mesna	warnings and precautions (oral label)	none in the top 1,000
Nafarelin	precautions	none in the top 1,000
Pamidronate	precautions	none in the top 1,000
Procainamide	precautions	none in the top 1,000
Taletrectinib adipate	warnings and precautions	none in the top 1,000
Atorvastatin	adverse reactions	9,961
Simvastatin	adverse reactions	8,443
Omeprazole	adverse reactions	5,878
Evolocumab	adverse reactions	5,419
Ezetimibe	adverse reactions	4,492
Lisinopril	adverse reactions	4,000
Dupilumab	adverse reactions	3,958
Amlodipine	adverse reactions	3,900
Methotrexate	adverse reactions	3,692
Rosuvastatin	adverse reactions	3,423
Pregabalin	adverse reactions	3,419
Clopidogrel	adverse reactions	2,964
Pantoprazole	adverse reactions	2,955
Esomeprazole	adverse reactions (intravenous label)	2,767
Losartan	adverse reactions	2,516
Tadalafil	adverse reactions	2,155
Alendronate	adverse reactions	2,103
Ramipril	adverse reactions	2,067
Selexipag	adverse reactions	1,981
Clonazepam	adverse reactions	1,966
Zoledronic acid	adverse reactions	1,866
Infliximab	adverse reactions	1,862
Escitalopram	adverse reactions	1,821
Interferon beta 1a	adverse reactions	1,814
Montelukast	adverse reactions	1,784
Allopurinol	adverse reactions	1,747
Omalizumab	adverse reactions	1,735
Treprostinil	adverse reactions	1,728
Alirocumab	adverse reactions	1,683
Fluticasone	adverse reactions (respiratory (inhalation) label)	1,664
Sildenafil	adverse reactions	1,660
Zolpidem	adverse reactions	1,659
Lenalidomide	adverse reactions	1,636
Citalopram	adverse reactions	1,575
Ribavirin	adverse reactions	1,372
Letrozole	adverse reactions	1,348
Rituximab	adverse reactions	1,289
Peginterferon alfa 2a	adverse reactions	1,251
Oxycodone	adverse reactions	1,240
Bupropion	adverse reactions	1,222
Mirtazapine	adverse reactions	1,185
Anastrozole	adverse reactions	1,081
Pembrolizumab	adverse reactions	1,017
Lamotrigine	adverse reactions	1,015
Baclofen	adverse reactions	988
Tiotropium	adverse reactions	988
Cyclosporine	adverse reactions	973
Azathioprine	adverse reactions	962
Trastuzumab	adverse reactions	929
Aripiprazole	adverse reactions	924
Cyclophosphamide	adverse reactions	909
Natalizumab	adverse reactions	909
Ofatumumab	adverse reactions	899
Fenofibrate	adverse reactions	896
Sitagliptin	adverse reactions	868
Ranitidine	adverse reactions	866
Paclitaxel	adverse reactions	862
Mycophenolate mofetil	adverse reactions	860
Isotretinoin	adverse reactions	850
Sulfamethoxazole and trimethoprim	adverse reactions	850
Pitavastatin	adverse reactions	845
Risedronate	adverse reactions	842
Nilotinib	adverse reactions	831
Acyclovir	adverse reactions	823
Docetaxel	adverse reactions	809
Relugolix	adverse reactions	802
Duloxetine	adverse reactions	800
Cyclobenzaprine	adverse reactions	775
Topiramate	adverse reactions	773
Insulin lispro	adverse reactions	760
Nivolumab	adverse reactions	712
Fluvastatin	adverse reactions	684
Ezetimibe and simvastatin	adverse reactions	675
Tacrolimus	adverse reactions	662
Pravastatin	adverse reactions	656
Diltiazem	adverse reactions	652
Budesonide	adverse reactions	640
Leuprolide	adverse reactions	637
Bevacizumab	adverse reactions	636
Varenicline	adverse reactions	627
Enalapril	adverse reactions	615
Exemestane	adverse reactions	615
Levetiracetam	adverse reactions	611
Fluconazole	adverse reactions	610
Mepolizumab	adverse reactions	569
Ustekinumab	adverse reactions	566
Estrogens conjugated	adverse reactions	559
Lovastatin	adverse reactions	559
Fingolimod	adverse reactions	546
Eculizumab	adverse reactions	529
Sumatriptan	adverse reactions (subcutaneous label)	529
Paroxetine	adverse reactions	524
Telmisartan	adverse reactions	521
Clarithromycin	adverse reactions	508
Colchicine	adverse reactions	506
Sofosbuvir	adverse reactions	488
Capecitabine	adverse reactions	472
Imatinib	adverse reactions	469
Pioglitazone	adverse reactions	463
Lenvatinib	adverse reactions	458
Human immunoglobulin g	adverse reactions	456
Botulinum toxin type a	adverse reactions	454
Risperidone	adverse reactions	453
Dexlansoprazole	adverse reactions	449
Buprenorphine	adverse reactions (transdermal label)	437
Gemfibrozil	adverse reactions	421
Tramadol	adverse reactions	420
Nifedipine	adverse reactions	419
Fulvestrant	adverse reactions	415
Cabozantinib	adverse reactions	403
Rabeprazole	adverse reactions	398
Pertuzumab	adverse reactions	393
Upadacitinib	adverse reactions	384
Naltrexone	adverse reactions	382
Mycophenolic acid	adverse reactions	368
Methylphenidate	adverse reactions	365
Epoprostenol	adverse reactions	357
Vemurafenib	adverse reactions	355
Ritonavir	adverse reactions	337
Isosorbide mononitrate	adverse reactions	332
Glyburide	adverse reactions	331
Niacin	adverse reactions	328

Source: FDA drug labels via openFDA, read October 8, 2026; FAERS via openFDA, reports through July 30, 2026

Which of them have the most muscle pain reports in FAERS?

Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; MedDRA preferred term “Myalgia”

What next?

Side effects across medicines: every reaction on PlainMeds
Report a side effect to the FDA: MedWatch