Prescription medicine
Carbamazepine Brand names: Tegretol, Carbatrol, Equetro
Carbamazepine (Tegretol) is a prescription medicine with an FDA approval on record since 1968. FDA's NDC Directory lists it from 42 generic labelers, and pharmacies paid $0.119 per carbamazepine 200 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
- A presentation discontinued
- Boxed warning
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the NDA 16608 record on Drugs@FDA; every carbamazepine label on DailyMed.
Highlights of the record
FDA label of August 20, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6 PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE RISK (SEE WARNINGS AND PRECAUTIONS, LABORATORY TESTS). APLASTIC ANEMIA AND AGRANULOCYTOSIS APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5 TO 8 TIMES GREATER THAN IN THE GENERAL POPULATION. […]
Used for
From the label: indications and usageEpilepsy Tegretol is indicated for use as an anticonvulsant drug.
Forms and strengths
- 100 mg
- 200 mg
- 300 mg
- 400 mg
- 100 mg/5ml
- 200 mg/10ml
Extended-release tablet; tablet; extended-release capsule; chewable tablet; suspension.
On the market
- Earliest approval on file
- March 11, 1968 Tegretol, Novartis; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 42 first August 14, 1986; 29 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 45 of which 42 under generic applications, 3 under brand applications, repackagers included
- Last listed patent
- January 31, 2040 Carnexiv injection; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $0.119 per tablet Carbamazepine 200 mg tablet
- Shortage (FDA)
- None current 3 past records
- Recalls by its makers (FDA)
- 11 since 2013 0 Class I among all firms' recalls; latest August 7, 2026; 3 more by firms not listed as its makers
- FAERS reports
- 66,615 through July 30, 2026
What is carbamazepine used for?
From the label: indications and usageEpilepsy Tegretol is indicated for use as an anticonvulsant drug. Evidence supporting efficacy of Tegretol as an anticonvulsant was derived from active drug-controlled studies that enrolled patients with the following seizure types: Partial seizures with complex symptomatology (psychomotor, temporal lobe). Patients with these seizures appear to show greater improvement than those with other types. Generalized tonic-clonic seizures (grand mal). Mixed seizure patterns which include the above, or other partial or generalized seizures. Absence seizures (petit mal) do not appear to be controlled by Tegretol (see PRECAUTIONS, General). […]
Conditions named in the indications of carbamazepine's FDA labels, with every medicine labeled for each:
From other carbamazepine labelsBipolar disorder and Seizures and epilepsy: A mood stabilizer indicated for the treatment of acute manic or mixed episodes associated with bipolar I disorder ( 1.1 ) Indicated for the treatment of the pain associated with trigeminal neuralgia ( 1.2 ) An anti-epileptic drug (AED) …
FDA pharmacologic class: Mood Stabilizer.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the patient leaflet for carbamazepine say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about TEGRETOL?Do not stop taking TEGRETOL without first talking to your healthcare provider. Stopping TEGRETOL suddenly can cause serious problems. TEGRETOL can cause serious side effects, including: TEGRETOL may cause rare but serious skin rashes that may lead to death. These serious skin reactions are more likely to happen when you begin taking TEGRETOL within the first four months of treatment but may occur at later times. These reactions can happen in anyone, but some types of skin reactions are more likely in people of Asian descent. If you are of Asian descent, you may need a genetic blood test before you take TEGRETOL to see if you are at a higher risk for serious skin reactions with this medicine. Reactions may include: skin rash hives sores in your mouth blistering or peeling of the skin round or oval patches, which can include redness, swelling, blistering, itching, peeling or darkening of the skin, that appear in the same place on your body as when you took Tegretol in the past. This may progress to a serious reaction. TEGRETOL may cause rare but serious blood problems. Symptoms may include: fever, sore throat, or other infections that come and go or do not go away easy bruising red or purple spots on your body bleeding gums or nose bleeds severe fatigue or weakness TEGRETOL may cause allergic reactions or serious problems, which may affect organs and other parts of your body like the liver or blood cells. You may or may not have a rash with these types of reactions. […]
From the patient leaflet: What should I avoid while taking TEGRETOL?Do not drink alcohol or take other drugs that make you sleepy or dizzy while taking TEGRETOL until you talk to your healthcare provider. TEGRETOL taken with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. Do not drive, operate heavy machinery, or do other dangerous activities until you know how TEGRETOL affects you. TEGRETOL may slow your thinking and motor skills.
From the patient leaflet: How should I store TEGRETOL?Store TEGRETOL Tablets at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F). Keep TEGRETOL Tablets dry. Store TEGRETOL-XR Tablets at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Keep TEGRETOL-XR Tablets dry. Do not store TEGRETOL Suspension above 30°C (86°F). Shake well before using. Keep TEGRETOL Suspension in a tight, light-resistant container. Keep TEGRETOL and all medicines out of the reach of children. General Information about TEGRETOL. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use TEGRETOL for a condition for which it was not prescribed. Do not give TEGRETOL to other people, even if they have the same symptoms that you have. It may harm them. This Medication Guide summarizes the most important information about TEGRETOL. […]
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
Is there a generic for carbamazepine (Tegretol)?
The FDA approved the first generic carbamazepine on August 14, 1986. 42 generic applications are approved; 29 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale. Drugs@FDA also holds 1 tentative approval: the FDA found the generic approvable, but patents or exclusivity keep it from final approval for now.
FDA's NDC Directory lists carbamazepine from 42 labelers under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
The Orange Book lists no patent for Tegretol oral suspension; a patent listed only for Carnexiv injection runs to January 31, 2040. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 1968 earliest approval on file
- 1986 first generic approved
- 2040 last listed patent
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for carbamazepine (Tegretol)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.119 per Carbamazepine 200 mg tablet, about the same as a year earlier. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Carbamazepine 200 mg tablet (generic)
- Tegretol 100 mg/5 mL suspension (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Carbamazepine 100 mg tablet chewable | Generic | $0.243 per tablet | $7.28 | -4% |
| Carbamazepine 100 mg/5 mL suspension | Generic | $0.0925 per mL | n/a | -17% |
| Carbamazepine 200 mg tablet | Generic | $0.119 per tablet | $3.58 | +0.6% |
| Carbamazepine ER 100 mg capsule | Generic | $1.07 per capsule | $32.04 | -2% |
| Carbamazepine ER 100 mg tablet | Generic | $0.202 per tablet | $6.06 | -22% |
| Carbamazepine ER 200 mg capsule | Generic | $1.05 per capsule | $31.58 | +0.2% |
| Carbamazepine ER 200 mg tablet | Generic | $0.399 per tablet | $11.97 | +3% |
| Carbamazepine ER 300 mg capsule | Generic | $1.07 per capsule | $32.24 | +2% |
| Carbamazepine ER 400 mg tablet | Generic | $0.653 per tablet | $19.58 | -2% |
| Carbatrol ER 100 mg capsule | Brand | $1.70 per capsule | $50.99 | +0.1% |
| Carbatrol ER 200 mg capsule | Brand | $1.69 per capsule | $50.80 | -0.2% |
| Carbatrol ER 300 mg capsule | Brand | $1.70 per capsule | $50.86 | -0.3% |
| Equetro 100 mg capsule | Brand | $3.65 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $109.59 | -0.8% |
| Equetro 200 mg capsule | Brand | $4.18 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $125.53 | +0.5% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Is carbamazepine in shortage?
No carbamazepine presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 3 records are all marked to be discontinued, the latest updated December 19, 2025. ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Carbatrol, Capsule, Extended Release, 100 mg (NDC 54092-171-12) | Takeda Pharmaceuticals USA Inc. | To Be Discontinued | December 19, 2025 |
| Carbatrol, Capsule, Extended Release, 200 mg (NDC 54092-172-12) | Takeda Pharmaceuticals USA Inc. | To Be Discontinued | December 19, 2025 |
| Carbatrol, Capsule, Extended Release, 300 mg (NDC 54092-173-12) | Takeda Pharmaceuticals USA Inc. | To Be Discontinued | December 19, 2025 |
Every carbamazepine presentation in the FDA shortage database
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
Has carbamazepine been recalled?
The FDA's Enforcement Report lists 14 recalls naming carbamazepine since 2013: 0 Class I (the most serious), 12 Class II, 2 Class III; 3 still ongoing. 3 of them are by firms that FDA's NDC Directory does not list as a maker of carbamazepine and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| August 7, 2026 | Class II | Golden State Medical Supply Inc. | CGMP deviations: tablets with black specks. |
| August 3, 2026 | Class II | SUN PHARMACEUTICAL INDUSTRIES INC | CGMP Deviations; black spots found on tablets from burnt excipient during manufacturing |
| September 15, 2025 | Class II | Amerisource Health Services LLC | Failed Dissolution Specifications. |
| December 2, 2021 | Class II | Torrent Pharma Inc. | Failed Dissolution Specifications |
| August 6, 2021 | Class II | The Harvard Drug Group | Failed Dissolution Specifications |
| June 29, 2020 | Class II | RemedyRepack Inc. | FAILED DISSOLUTION SPECIFICATION: Low out-of-specification (OOS) dissolution results obtained during routine stability testing. |
| May 11, 2020 | Class II | Torrent Pharma Inc. | Failed Dissolution Specifications |
| August 9, 2019 | Class II | American Health Packaging | Failed Dissolution Specifications |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the carbamazepine label say about other medicines?
The carbamazepine label names 105 other medicines in its interaction, contraindication or warning sections. The labels of 33 other medicines name carbamazepine. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Acetaminophen | drug interactions | In addition, Tegretol causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g. … |
| Acetazolamide | drug interactions | … isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors. |
| Albendazole | drug interactions | In addition, Tegretol causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g. … |
| Alprazolam | drug interactions | In addition, Tegretol causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g. … |
| Aminophylline | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Amitriptyline | contraindications | CONTRAINDICATIONS Tegretol should not be used in patients with a history of previous bone marrow depression, hypersensitivity to the drug, or known sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. … |
| Apixaban | drug interactions | Concomitant use of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban (direct acting oral anticoagulants) is expected to result in decreased plasma concentrations of these anticoagulants that may be insufficient to achieve the intended therapeutic effect. |
| Aprepitant | drug interactions | Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g. … |
| Aripiprazole | drug interactions | When carbamazepine is added to aripiprazole, the aripiprazole dose should be doubled. |
| Brivaracetam | drug interactions | Accordingly, the dosage of Tegretol should be adjusted and/or the plasma levels monitored when used concomitantly with loxapine, quetiapine, valproic acid, or brivaracetam. |
| Buprenorphine | drug interactions | Acetaminophen, albendazole, alprazolam, aprepitant, buprenorphine, apixaban (6), bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, corticosteroids (e.g. prednisolone, dexamethasone), cyclosporin, dabigatran (6), delavirdine, desipramine, diazepam, dicumarol, dihydropyridine calcium channel blockers … |
| Bupropion | drug interactions | In addition, Tegretol causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g. … |
| Buspirone | drug interactions | Acetaminophen, albendazole, alprazolam, aprepitant, buprenorphine, apixaban (6), bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, corticosteroids (e.g. prednisolone, dexamethasone), cyclosporin, dabigatran (6), delavirdine, desipramine, diazepam, dicumarol, dihydropyridine calcium channel blockers … |
| Chloroquine | drug interactions | Chloroquine and Mefloquine Anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine. |
Every other medicine the carbamazepine label names
| Medicine named | Section | What the label says |
|---|---|---|
| Chlorpromazine | drug interactions | Subsequent testing has shown that mixing Tegretol suspension and chlorpromazine solution (both generic and brand name) as well as Tegretol suspension and liquid Mellaril ® , resulted in the … |
| Cimetidine | drug interactions | Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin … |
| Ciprofloxacin | drug interactions | Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin … |
| Cisatracurium | drug interactions | Resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuronium, vecuronium, rocuronium and cisatracurium has occurred in patients chronically … |
| Cisplatin | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin … |
| Citalopram | drug interactions | … acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol … |
| Clarithromycin | drug interactions | … ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g. … |
| Clobazam | drug interactions | Acetaminophen, albendazole, alprazolam, aprepitant, buprenorphine, apixaban (6), bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, corticosteroids (e.g. … |
| Clomipramine | drug interactions | Clomipramine HCl, Phenytoin (7), and Primidone Carbatrol can increase the concentrations of clomipramine, phenytoin, and primidone. |
| Clonazepam | drug interactions | … albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium … |
| Clozapine | drug interactions | … alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel … |
| Cyclophosphamide | drug interactions | The rate of metabolism and the leukopenic activity of cyclophosphamide are reportedly increased by chronic coadministration of CYP3A4 inducers. |
| Cyclosporine | drug interactions | … clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, eslicarbazepine … |
| Dabigatran | drug interactions | Concomitant use of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban (direct acting oral anticoagulants) is expected to result in decreased plasma concentrations of these … |
| Danazol | drug interactions | Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin … |
| Dantrolene | drug interactions | Concomitant use of carbamazepine with olanzapine, dantrolene, or ibuprofen may increase plasma carbamazepine levels. |
| Desipramine | contraindications | … sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. … |
| Dexamethasone | drug interactions | … citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline … |
| Diazepam | drug interactions | … dexamethasone), cyclosporin, dabigatran (6), delavirdine, desipramine, diazepam, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, edoxaban (6), eslicarbazepine … |
| Diltiazem | drug interactions | Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin … |
| Divalproex | drug interactions | Accordingly, the dosage of Tegretol should be adjusted and/or the plasma levels monitored when used concomitantly with loxapine, quetiapine, valproic acid, or brivaracetam. |
| Doxorubicin | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin … |
| Doxycycline | drug interactions | … dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine … |
| Edoxaban | drug interactions | Concomitant use of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban (direct acting oral anticoagulants) is expected to result in decreased plasma concentrations of these … |
| Erythromycin | drug interactions | … aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide … |
| Eslicarbazepine | drug interactions | … dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone … |
| Ethosuximide | drug interactions | … channel blockers (e.g., felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin … |
| Everolimus | drug interactions | … blockers (e.g., felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam … |
| Felbamate | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin … |
| Felodipine | drug interactions | … cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine … |
| Fluconazole | drug interactions | … niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors. |
| Fluoxetine | drug interactions | … danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole … |
| Fluvoxamine | drug interactions | … diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole … |
| Fosphenytoin | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin … |
| Haloperidol | drug interactions | … felodipine), doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral … |
| Ibuprofen | drug interactions | Concomitant use of carbamazepine with olanzapine, dantrolene, or ibuprofen may increase plasma carbamazepine levels. |
| Imatinib | drug interactions | … doxycycline, eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other … |
| Imipramine | contraindications | … any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. Likewise, on theoretical grounds its use with monoamine oxidase (MAO) inhibitors is … |
| Isoniazid | drug interactions | … clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole) … |
| Itraconazole | drug interactions | … isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors. |
| Ketoconazole | drug interactions | Acetazolamide, aprepitant, azole antifungals (e.g., ketoconazole, itraconazole, fluconazole, voriconazole), cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine … |
| Lamotrigine | drug interactions | … eslicarbazepine, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal … |
| Levonorgestrel | drug interactions | Concomitant use of Tegretol with hormonal contraceptive products (e.g., oral, and levonorgestrel subdermal implant contraceptives) may render the contraceptives less effective because the plasma … |
| Levothyroxine | drug interactions | … ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal contraceptives … |
| Lithium | drug interactions | Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects. |
| Loratadine | drug interactions | … erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, macrolides, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, protease inhibitors … |
| Lorazepam | drug interactions | … felbamate, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, methsuximide, midazolam, mirtazapine, nefazodone, nortriptyline, olanzapine, oral and other hormonal … |
| Loxapine | drug interactions | Accordingly, the dosage of Tegretol should be adjusted and/or the plasma levels monitored when used concomitantly with loxapine, quetiapine, valproic acid, or brivaracetam. |
| Mefloquine | drug interactions | Chloroquine and Mefloquine Anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine. |
| Methadone | drug interactions | … everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal contraceptives, oxcarbazepine … |
| Methsuximide | drug interactions | … felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Midazolam | drug interactions | … itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal contraceptives, oxcarbazepine, paliperidone, phensuximide, phenytoin … |
| Mirtazapine | drug interactions | … lamotrigine, levothyroxine, lorazepam, methadone, methsuximide, midazolam, mirtazapine, nefazodone, nortriptyline, olanzapine, oral and other hormonal contraceptives (2), oxcarbazepine, paliperidone … |
| Nefazodone | contraindications | Coadministration of carbamazepine and nefazodone may result in insufficient plasma concentrations of nefazodone and its active metabolite to achieve a therapeutic effect. |
| Nortriptyline | contraindications | … compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. Likewise, on theoretical grounds its use with monoamine oxidase (MAO) inhibitors is not recommended. |
| Olanzapine | drug interactions | … lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal contraceptives, oxcarbazepine, paliperidone, phensuximide, phenytoin, praziquantel … |
| Omeprazole | drug interactions | … erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole) … |
| Oxcarbazepine | drug interactions | … mianserin, midazolam, olanzapine, oral and other hormonal contraceptives, oxcarbazepine, paliperidone, phensuximide, phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus … |
| Oxybutynin | drug interactions | … erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole) … |
| Paliperidone | drug interactions | … olanzapine, oral and other hormonal contraceptives, oxcarbazepine, paliperidone, phensuximide, phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil … |
| Phenobarbital | drug interactions | … include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Phenytoin | drug interactions | Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin … |
| Praziquantel | drug interactions | … contraceptives, oxcarbazepine, paliperidone, phensuximide, phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol … |
| Prednisolone | drug interactions | … bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline … |
| Primidone | drug interactions | … HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Protriptyline | contraindications | … tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. Likewise, on theoretical grounds its use with monoamine oxidase (MAO) inhibitors is not … |
| Quetiapine | drug interactions | Accordingly, the dosage of Tegretol should be adjusted and/or the plasma levels monitored when used concomitantly with loxapine, quetiapine, valproic acid, or brivaracetam. |
| Quinine | drug interactions | … olanzapine, omeprazole, oxybutynin, protease inhibitors, propoxyphene, quinine, quinupristin, ticlopidine, troleandomycin, valproate, verapamil, zileuton. |
| Rifampin | drug interactions | … levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Risperidone | drug interactions | … paliperidone, phensuximide, phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic … |
| Rivaroxaban | drug interactions | Concomitant use of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban (direct acting oral anticoagulants) is expected to result in decreased plasma concentrations of these … |
| Rocuronium | drug interactions | Resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuronium, vecuronium, rocuronium and cisatracurium has occurred in patients chronically … |
| Sertraline | drug interactions | … phensuximide, phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g. … |
| Sirolimus | drug interactions | … phenytoin, praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g., imipramine … |
| Tacrolimus | drug interactions | When carbamazepine is used with tacrolimus, monitoring of tacrolimus blood concentrations and appropriate dosage adjustments are recommended. |
| Tadalafil | drug interactions | … praziquantel, protease inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g., imipramine, amitriptyline … |
| Temsirolimus | drug interactions | The use of concomitant strong CYP3A4 inducers, such as carbamazepine should be avoided with temsirolimus. |
| Theophylline | drug interactions | … fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline. |
| Tiagabine | drug interactions | … inhibitors, risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g., imipramine, amitriptyline, nortriptyline) … |
| Topiramate | drug interactions | … risperidone, sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g., imipramine, amitriptyline, nortriptyline), valproate … |
| Tramadol | drug interactions | … sertraline, sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, trazodone, tricyclic antidepressants (e.g., imipramine, amitriptyline, nortriptyline), valproate, warfarin … |
| Trazodone | drug interactions | … macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole … |
| Triazolam | drug interactions | … sirolimus, tadalafil, theophylline, tiagabine, topiramate, tramadol, triazolam, trazodone (4), tricyclic antidepressants (e.g., imipramine, amitriptyline, nortriptyline), valproate, warfarin (5) … |
| Valproic acid | drug interactions | Accordingly, the dosage of Tegretol should be adjusted and/or the plasma levels monitored when used concomitantly with loxapine, quetiapine, valproic acid, or brivaracetam. |
| Vecuronium | drug interactions | Resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents pancuronium, vecuronium, rocuronium and cisatracurium has occurred in patients chronically … |
| Verapamil | drug interactions | … ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors. |
| Voriconazole | drug interactions | … (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors. |
| Warfarin | drug interactions | … antidepressants (e.g., imipramine, amitriptyline, nortriptyline), valproate, warfarin, ziprasidone, zonisamide. |
| Zileuton | drug interactions | … quinine, quinupristin, ticlopidine, troleandomycin, valproate, verapamil, zileuton. |
| Ziprasidone | drug interactions | … (e.g., imipramine, amitriptyline, nortriptyline), valproate, warfarin, ziprasidone, zonisamide. |
| Zonisamide | drug interactions | … imipramine, amitriptyline, nortriptyline), valproate, warfarin, ziprasidone, zonisamide. |
Other labels that name carbamazepine
- Apremilast
- Aripiprazole lauroxil
- Atazanavir
- Cabotegravir
- Cabozantinib
- Cefixime
- Cobicistat
- Cobimetinib
- Codeine
- Darunavir
- Deflazacort
- Desmopressin
- Dolutegravir
- Donepezil and memantine
- Doravirine
- Dronedarone
- Drospirenone
- Efavirenz
- Elbasvir and grazoprevir
- Ensitrelvir
- Enzalutamide
- Erlotinib
- Estazolam
- Estradiol
- Estrogens conjugated
- Ethinyl estradiol and norelgestromin
- Ethinyl estradiol and norgestimate
- Etonogestrel
- Etravirine
- Exemestane
- Fentanyl
- Fesoterodine
- Fexinidazole
- Folic acid
- Fosamprenavir
- Fostemsavir
- Ganaxolone
- Hydrochlorothiazide and irbesartan
- Hydrocodone
- Hydrocortisone
- Irinotecan
- Istradefylline
- Ixazomib
- Ketorolac
- Lapatinib ditosylate
- Lemborexant
- Lenacapavir
- Letermovir
- Lurasidone
- Maribavir
- Meperidine
- Methylprednisolone
- Metronidazole
- Mifepristone
- Nelfinavir
- Nevirapine
- Norethindrone
- Oliceridine
- Ondansetron
- Osilodrostat
- Oxycodone
- Paclitaxel
- Palbociclib
- Perampanel
- Phenelzine
- Ranolazine
- Rilpivirine
- Ritonavir
- Roflumilast
- Rufinamide
- Selegiline
- Sofosbuvir
- Stiripentol
- Sufentanil
- Suvorexant
- Tenofovir alafenamide
- Thiothixene
- Ticagrelor
- Triamcinolone
- Vemurafenib
- Vilazodone
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What do FAERS reports show for carbamazepine?
The FDA Adverse Event Reporting System holds 66,615 reports that list carbamazepine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 5,605 are coded as a death and 25,899 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as carbamazepine?
6 other medicines are given the same way (oral) and in the same FDA class as carbamazepine or labeled mainly for the same use (bipolar disorder), the same class first. Bipolar disorder lists all 17 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Lamotrigine | Bipolar disorder, Seizures and epilepsy | 50 labelers | $0.0268 per tablet 25 mg tablet | A presentation being discontinued |
| Divalproex | Bipolar disorder, Seizures and epilepsy | 44 labelers | $0.194 per tablet 500 mg tablet | No current entry |
| Lithium | Bipolar disorder | 24 labelers | $0.104 per capsule 300 mg capsule | No current entry |
| Valproic acid | Seizures and epilepsy | 19 labelers | $0.243 per capsule 250 mg capsule | Listed; available |
| Risperidone | Bipolar disorder | 35 labelers | $0.0368 per tablet 0.25 mg tablet | No current entry |
| Ziprasidone | Bipolar disorder | 16 labelers | $0.269 per capsule 20 mg capsule | No current entry |
Every medicine labeled for the same conditions as carbamazepine
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does carbamazepine compare with medicines for the same use?
16 side-by-side pages set carbamazepine beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to carbamazepine
- 6 medicines for the same use
- Other mood stabilizers
- the pharmacologic class, with prices and generics
- Carbamazepine side effects
- the label's list beside FAERS reports
- Carbamazepine shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other