Dolutegravir and Carbamazepine Interaction
Drug interaction information between Dolutegravir and Carbamazepine.
Dolutegravir and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes the body get rid of dolutegravir faster, which lowers the amount of medicine in your blood.
FDA Label Information
Carbamazepine a ↓Dolutegravir In adults and in pediatric patients weighing at least 25 kg , adjust dolutegravir dose to 50 mg twice daily.
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Dolutegravir's 28. In the minor band specifically: Dolutegravir has 21 (also Omeprazole, Prednisone, Estradiol, Rifampin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Dolutegravir and Carbamazepine?
Carbamazepine makes the body get rid of dolutegravir faster, which lowers the amount of medicine in your blood.
Carbamazepine carries more major-labeled pairs than Dolutegravir
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir (Integrase Strand Transfer Inhibitor); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Dolutegravir's 1. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Prednisone
- Estradiol
- Rifampin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.