Carbamazepine · more major-labeled pairs than Bupropion

SPL labels Bupropion + Carbamazepine as minor; Bupropion 32 / Carbamazepine 110 in that band.

Mechanism on file: Carbamazepine makes your body break down bupropion faster, which can lower the amount of medicine in your blood.

FDA SPL severity: Minor

Bupropion

Full Bupropion label record

Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)

Carbamazepine

Full Carbamazepine label record

Anticonvulsant

Bupropion + Carbamazepine · SPL mechanism field

Carbamazepine makes your body break down bupropion faster, which can lower the amount of medicine in your blood.

Minor band excerpt · Bupropion with Carbamazepine

7 DRUG INTERACTIONS CYP2B6 inducers: Dose increase may be necessary if coadministered with CYP2B6 inducers (e.g., ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, and phenytoin) based on clinical exposure, but should not exceed the maximum recommended dose. Carbamazepine, Phenobarbital, Phenytoin: While not systemically studied, these drugs may induce metabolism of bupropion and may decrease bupropion exposure [see Clinical Pharmacology (12.3) ].

Bupropion · 32 minor + 35 total pairs

View all Bupropion interactions →

Carbamazepine · 3 major-labeled pairs (vs Bupropion's 1)

View all Carbamazepine interactions →

FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.