What the FDA labels say about taking them together
Carbamazepine and perampanel
Perampanel's FDA label of September 1, 2024 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name perampanel. The perampanel label: “DRUG INTERACTIONS Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel Moderate and Strong CYP3A4 Inducers: increase clearance of perampanel and decrease …”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the perampanel FDA label on DailyMed (effective September 1, 2024, Teva Pharmaceuticals, Inc.).
What does the carbamazepine label say about perampanel?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name perampanel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the perampanel label say about carbamazepine?
Perampanel label, drug interactionsDRUG INTERACTIONS Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel ( 7.1 ) Moderate and Strong CYP3A4 Inducers (including carbamazepine, oxcarbazepine, and phenytoin): increase clearance of perampanel and decrease perampanel plasma concentrations.
Source: FDA drug label (Perampanel), Teva Pharmaceuticals, Inc., effective September 1, 2024 (SPL set bc8f7cf2-c19c-4235-859f-9ff1dd21908e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Perampanel | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $14.43 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once