What the FDA labels say about taking them together
Carbamazepine and clomipramine
Carbamazepine's FDA label (Carbatrol) of August 17, 2026 names clomipramine in its drug interactions section; the clomipramine label PlainMeds reads does not name carbamazepine. The carbamazepine label: “Clomipramine, P henytoin, and P rimidone EQUETRO can increase the concentrations of clomipramine, phenytoin, and primidone.”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the clomipramine FDA label on DailyMed (effective November 26, 2024).
What does the carbamazepine label say about clomipramine?
Carbatrol label (Takeda Pharmaceuticals America, Inc., August 17, 2026), drug interactionsClomipramine HCl, Phenytoin (7), and Primidone Carbatrol can increase the concentrations of clomipramine, phenytoin, and primidone.
Source: FDA drug label (Carbatrol, NDA020712), Takeda Pharmaceuticals America, Inc., effective August 17, 2026 (SPL set bc03e499-5bac-4293-bff4-6864153a624d), via openFDA
Source: FDA drug label (Equetro, NDA021710), Validus Pharmaceuticals LLC, effective August 19, 2025 (SPL set be478f3c-40f6-47cc-8ab9-f420a9372b1c), via openFDA
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the clomipramine label say about carbamazepine?
Clomipramine's label (effective November 26, 2024) does not name carbamazepine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Clomipramine | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $0.189 per capsule 25 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once