Apixaban and Carbamazepine Interaction
Drug interaction information between Apixaban and Carbamazepine.
Apixaban and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Apixaban and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your body break down apixaban too fast, which lowers the drug levels in your blood. This makes the medicine less effective at preventing dangerous blood clots.
FDA Label Information
7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Rifampin moderate
- Heparin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Desmopressin moderate
Frequently Asked Questions
What SPL severity band is on file for Apixaban + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Apixaban has 9 (also Clopidogrel, Aspirin, Warfarin, Rifampin); Carbamazepine has 16 (also Lithium, Desmopressin, Dronedarone, Fluconazole).
What mechanism field is on file for Apixaban and Carbamazepine?
Carbamazepine makes your body break down apixaban too fast, which lowers the drug levels in your blood. This makes the medicine less effective at preventing dangerous blood clots.
Carbamazepine carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Warfarin
- Rifampin
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Desmopressin
- Dronedarone
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.