Lemborexant and Carbamazepine Interaction
Drug interaction information between Lemborexant and Carbamazepine.
Lemborexant and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lemborexant and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to process lemborexant much faster, which makes the sleep medicine less effective.
FDA Label Information
Examples: Strong CYP3A inducers: rifampin, carbamazepine, St.
Lemborexant Also Interacts With
- Fluconazole moderate
- Voriconazole moderate
- Bupropion minor
- Verapamil minor
- Clarithromycin minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Lemborexant's 11. In the minor band specifically: Lemborexant has 9 (also Bupropion, Verapamil, Clarithromycin, Rifampin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Lemborexant and Carbamazepine?
Carbamazepine causes your body to process lemborexant much faster, which makes the sleep medicine less effective.
Carbamazepine carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is minor · classes on file: Lemborexant (Orexin Receptor Antagonist); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Lemborexant's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Lemborexant
- Bupropion
- Verapamil
- Clarithromycin
- Rifampin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.