What the FDA labels say about taking them together
Carbamazepine and darunavir
Darunavir's FDA label of August 29, 2025 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name darunavir. The darunavir label: “The dose of either PREZISTA/ritonavir or carbamazepine does not need to be adjusted when initiating co-administration with PREZISTA/ritonavir and carbamazepine. …”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the carbamazepine label say about darunavir?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the darunavir label say about carbamazepine?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Anticonvulsants: carbamazepine; Effect on Concentration of Darunavir Or Concomitant Drug: ↔ darunavir ↑ carbamazepine; Clinical Comment: The dose of either PREZISTA/ritonavir or carbamazepine does not need to be adjusted when initiating co-administration with PREZISTA/ritonavir and carbamazepine. Clinical monitoring of carbamazepine concentrations and its dose titration is recommended to achieve the desired clinical response.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Darunavir | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once