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What the FDA labels say about taking them together

Carbamazepine and thiothixene

Thiothixene's FDA label of November 16, 2024 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name thiothixene. The thiothixene label: “Drug Interactions Hepatic microsomal enzyme inducing agents, such as carbamazepine, were found to significantly increase the clearance of thiothixene.”

Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the thiothixene FDA label on DailyMed (effective November 16, 2024, Amneal Pharmaceuticals NY LLC).

What does the carbamazepine label say about thiothixene?

Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name thiothixene in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed

What does the thiothixene label say about carbamazepine?

Thiothixene label, drug interactions

Drug Interactions Hepatic microsomal enzyme inducing agents, such as carbamazepine, were found to significantly increase the clearance of thiothixene.

Source: FDA drug label (thiothixene), Amneal Pharmaceuticals NY LLC, effective November 16, 2024 (SPL set 81c40311-7dc4-4332-8920-a39a8466aea6), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

42Carbamazepine generic labelers
4Thiothixene generic labelers
CarbamazepineThiothixene
Labeled forBipolar disorder, Seizures and epilepsySchizophrenia
Boxed warningYesYes
Pharmacy cost (NADAC)$0.119 per tablet 200 mg tablet$1.72 per capsule 10 mg capsule
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?