Nortriptyline and Carbamazepine Interaction
Drug interaction information between Nortriptyline and Carbamazepine.
Nortriptyline and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nortriptyline and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how your body breaks down nortriptyline, which can lower the amount of medicine in your blood.
FDA Label Information
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Nortriptyline Also Interacts With
- Bupropion minor
- Darunavir minor
- Dopamine minor
- Fluconazole minor
- Norepinephrine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Nortriptyline + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Nortriptyline has 8 (also Bupropion, Darunavir, Dopamine, Fluconazole); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Nortriptyline and Carbamazepine?
Carbamazepine speeds up how your body breaks down nortriptyline, which can lower the amount of medicine in your blood.
Carbamazepine carries more major-labeled pairs than Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Nortriptyline (Tricyclic Antidepressant (TCA)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Nortriptyline's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Bupropion
- Darunavir
- Dopamine
- Fluconazole
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.