What the FDA labels say about taking them together
Carbamazepine and voriconazole
Carbamazepine's FDA label of August 20, 2026 names voriconazole in its drug interactions section, and voriconazole's label names carbamazepine too. The voriconazole label: “Contraindicated”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the carbamazepine label say about voriconazole?
Carbamazepine label, drug interactionsDrugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors.
Carbatrol label (Takeda Pharmaceuticals America, Inc., August 17, 2026), drug interactionsAcetazolamide, aprepitant, azole antifungals (e.g., ketoconazole, itraconazole, fluconazole, voriconazole), cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine, diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, macrolides, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, protease inhibitors, propoxyphene, quinine, quinupristin, ticlopidine, troleandomycin, valproate, verapamil, zileuton.
Equetro label (Validus Pharmaceuticals LLC, August 19, 2025), drug interactionsThe following drugs are CYP3A4 inhibitors: Acetazolamide, aprepitant, azole antifungals (e.g., ketoconazole, itraconazole, fluconazole, voriconazole ), cimetidine, ciprofloxacin, clarithromycin, dalfopristin, danazol, dantrolene, delavirdine, diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, ibuprofen, isoniazid, loratadine, nefazodone, niacinamide, nicotinamide, olanzapine, omeprazole, oxybutynin, quinine, quinupristin, ticlopidine, troleandomycin, valproate, verapamil, zileuton.
Source: FDA drug label (Carbatrol, NDA020712), Takeda Pharmaceuticals America, Inc., effective August 17, 2026 (SPL set bc03e499-5bac-4293-bff4-6864153a624d), via openFDA
Source: FDA drug label (Equetro, NDA021710), Validus Pharmaceuticals LLC, effective August 19, 2025 (SPL set be478f3c-40f6-47cc-8ab9-f420a9372b1c), via openFDA
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the voriconazole label say about carbamazepine?
Voriconazole label, contraindicationsCarbamazepine
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Carbamazepine (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Not Studied In Vivo or In Vitro, but Likely to Result in Significant Reduction; Prevention or Management Recommendations: Contraindicated
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), contraindicationsCoadministration of Voriconazole for injection with rifampin, carbamazepine, long-acting barbiturates and St. John's Wort is contraindicated because these drugs are likely to decrease plasma voriconazole concentrations significantly [see Drug Interactions (7) and Clinical Pharmacology (12.3) ].
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Carbamazepine (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Not Studied In Vivo or In Vitro, but Likely to Result in Significant Reduction; Recommendations for Voriconazole Dosage Adjustment/Comments: Contraindicated
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Voriconazole | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once