What the FDA labels say about taking them together
Carbamazepine and ketorolac
Ketorolac's FDA label (Sprix) of December 5, 2024 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name ketorolac.
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC).
What does the carbamazepine label say about ketorolac?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name ketorolac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the ketorolac label say about carbamazepine?
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: Sporadic cases of seizures have been reported during concomitant use of ketorolac and antiepileptic drugs (phenytoin, carbamazepine). Intervention: During concomitant use of SPRIX and antiepileptic drugs, monitor patients for seizures.
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Ketorolac | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $1.02 per mL 30 mg/mL vial |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once