Fluoxetine and Carbamazepine Interaction
Drug interaction information between Fluoxetine and Carbamazepine.
Fluoxetine and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluoxetine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the liver from breaking down this medication properly. This can cause the drug to reach high levels in your body, which may be harmful.
FDA Label Information
Monoamine Oxidase Inhibitors (MAOIs): ( 2.9 , 2.10 , 4.1 , 5.2 ) Drugs Metabolized by CYP2D6: Fluoxetine is a potent inhibitor of CYP2D6 enzyme pathway ( 7.7 ) Tricyclic Antidepressants (TCAs): Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued ( 5.2 , 7.7 ) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs ( 7.2 ) Benzodiazepines: Diazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels ( 7.7 ) Antipsychotics: Potential for elevation...
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Fluoxetine + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Fluoxetine's 68. In the moderate band specifically: Fluoxetine has 19 (also Alprazolam, Diazepam, Haloperidol, Clozapine); Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone).
What mechanism field is on file for Fluoxetine and Carbamazepine?
Fluoxetine blocks the liver from breaking down this medication properly. This can cause the drug to reach high levels in your body, which may be harmful.
Fluoxetine carries more major-labeled pairs than Carbamazepine
SPL source-record counts only. This page's band is moderate · classes on file: Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Carbamazepine (Anticonvulsant).
Fluoxetine has 6 major-labeled pairs vs Carbamazepine's 3. This page itself is in the moderate band, not the major band.
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Haloperidol
- Clozapine
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.