Buprenorphine and Carbamazepine Interaction
Drug interaction information between Buprenorphine and Carbamazepine.
Buprenorphine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to break down buprenorphine more quickly, which can lower the amount of medicine in your system.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Antiretrovirals: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Clinical Impact: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are metabolized principally by CYP3A4.
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Buprenorphine's 29. In the minor band specifically: Buprenorphine has 28 (also Trazodone, Cyclobenzaprine, Mirtazapine, Ketoconazole); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Buprenorphine and Carbamazepine?
Carbamazepine causes your body to break down buprenorphine more quickly, which can lower the amount of medicine in your system.
Carbamazepine carries more major-labeled pairs than Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine (Partial Opioid Agonist); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Buprenorphine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Ketoconazole
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.