What the FDA labels say about taking them together
Carbamazepine and stiripentol
Stiripentol's FDA label of April 27, 2026 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name stiripentol. The stiripentol label: “Because of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19, P-gp (e.g., carbamazepine), and BCRP, if adverse reactions are experienced when …”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).
What does the carbamazepine label say about stiripentol?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the stiripentol label say about carbamazepine?
Stiripentol label, drug interactionsBecause of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19 (e.g., diazepam, clopidogrel), P-gp (e.g., carbamazepine), and BCRP (e.g., methotrexate, prazosin, glyburide), if adverse reactions are experienced when administered concomitantly with DIACOMIT.
Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Stiripentol | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once