Carbamazepine and Ibuprofen Interaction
Drug interaction information between Carbamazepine and Ibuprofen.
Carbamazepine and Ibuprofen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbamazepine and Ibuprofen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ibuprofen can cause carbamazepine to build up in your blood by slowing down how your body processes it.
FDA Label Information
Concomitant use of carbamazepine with olanzapine, dantrolene, or ibuprofen may increase plasma carbamazepine levels.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Digoxin minor
- Fluconazole minor
- Prenatal Multivitamin minor
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Ibuprofen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Ibuprofen's 9. In the minor band specifically: Carbamazepine has 110 (also Omeprazole, Citalopram, Amitriptyline, Acetaminophen); Ibuprofen has 7 (also Digoxin, Fluconazole, Prenatal Multivitamin, Terazosin).
What mechanism field is on file for Carbamazepine and Ibuprofen?
Ibuprofen can cause carbamazepine to build up in your blood by slowing down how your body processes it.
Carbamazepine carries more major-labeled pairs than Ibuprofen
SPL source-record counts only. This page's band is minor · classes on file: Carbamazepine (Anticonvulsant); Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Carbamazepine has 3 major-labeled pairs vs Ibuprofen's 0. This page itself is in the minor band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Citalopram
- Amitriptyline
- Acetaminophen
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ibuprofen
- Digoxin
- Fluconazole
- Prenatal Multivitamin
- Terazosin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.