Ranolazine and Carbamazepine Interaction
Drug interaction information between Ranolazine and Carbamazepine.
Ranolazine and Carbamazepine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ranolazine and Carbamazepine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should.
What To Do
Avoid using these drugs together to make sure your treatment stays effective.
FDA Label Information
CYP3A Inducers Do not use ranolazine with CYP3A inducers such as rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, and St.
Ranolazine Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Rifampin major
- Phenytoin major
- Phenobarbital major
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Risperidone major
- Lithium moderate
- Apixaban moderate
- Desmopressin moderate
Frequently Asked Questions
Can I take Ranolazine and Carbamazepine together?
This is a major interaction. Avoid using these drugs together to make sure your treatment stays effective.
How serious is the interaction between Ranolazine and Carbamazepine?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Ranolazine and Carbamazepine interact?
Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should.
Understanding the Ranolazine and Carbamazepine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Ranolazine belongs to the Late Sodium Current Inhibitor (Antianginal) class and Carbamazepine belongs to the Anticonvulsant class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ranolazine has 31 total documented interactions on file in this dataset, and Carbamazepine has 129. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these drugs together to make sure your treatment stays effective. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ranolazine or Carbamazepine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.