Suvorexant and Carbamazepine Interaction
Drug interaction information between Suvorexant and Carbamazepine.
Suvorexant and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Suvorexant and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how quickly your body gets rid of suvorexant, which can significantly lower the amount of medicine in your blood.
FDA Label Information
CYP3A Inducers Suvorexant exposure can be substantially decreased when co-administered with strong CYP3A inducers (e.g., rifampin, carbamazepine and phenytoin).
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Diltiazem minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Suvorexant's 15. In the minor band specifically: Suvorexant has 11 (also Diltiazem, Ciprofloxacin, Fluconazole, Verapamil); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Suvorexant and Carbamazepine?
Carbamazepine speeds up how quickly your body gets rid of suvorexant, which can significantly lower the amount of medicine in your blood.
Carbamazepine carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is minor · classes on file: Suvorexant (Orexin Receptor Antagonist); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Suvorexant's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Suvorexant
- Diltiazem
- Ciprofloxacin
- Fluconazole
- Verapamil
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.