What the FDA labels say about taking them together
Carbamazepine and suvorexant
Suvorexant's FDA label of March 10, 2025 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name suvorexant. The suvorexant label: “CYP3A Inducers Suvorexant exposure can be substantially decreased when co-administered with strong CYP3A inducers.”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the suvorexant FDA label on DailyMed (effective March 10, 2025, Merck Sharp & Dohme LLC).
What does the carbamazepine label say about suvorexant?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name suvorexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the suvorexant label say about carbamazepine?
Suvorexant label, drug interactionsCYP3A Inducers Suvorexant exposure can be substantially decreased when co-administered with strong CYP3A inducers (e.g., rifampin, carbamazepine and phenytoin).
Source: FDA drug label (BELSOMRA), Merck Sharp & Dohme LLC, effective March 10, 2025 (SPL set e5b72731-1acb-45b7-9c13-290ad12d3951), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Suvorexant | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $15.21 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once