Carbamazepine and Amitriptyline Interaction
Drug interaction information between Carbamazepine and Amitriptyline.
Carbamazepine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbamazepine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up the way your body clears amitriptyline, which can make the antidepressant less effective.
FDA Label Information
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Acetaminophen); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Carbamazepine and Amitriptyline?
Carbamazepine speeds up the way your body clears amitriptyline, which can make the antidepressant less effective.
Carbamazepine carries more major-labeled pairs than Amitriptyline
SPL source-record counts only. This page's band is minor · classes on file: Carbamazepine (Anticonvulsant); Amitriptyline (Tricyclic Antidepressant (TCA)).
Carbamazepine has 3 major-labeled pairs vs Amitriptyline's 1. This page itself is in the minor band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Acetaminophen
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.