ziprasidone

Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St.

Mechanism: Both of these drugs increase a chemical in the brain called serotonin. Having too much serotonin can lead to a dangerous condition called serotonin syndrome.

What to do: Tell your doctor if you feel very restless, confused, or have a fast heartbeat. Your doctor will decide if it is safe for you to take both medicines.

Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. 7.5 Lithium Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. Ziprasidone dosed adjunctively to lithium in a maintenance trial of bipolar patients did not affect mean therapeutic lithium levels.

Mechanism: These drugs can both raise serotonin levels in the body. When used together, they may cause a serious reaction called serotonin syndrome.

What to do: Your doctor should monitor you for symptoms like muscle stiffness or fever. Do not stop taking your medicine without talking to your provider first.

7.5 Drugs That Cause QTc Prolongation Tetrabenazine causes a small prolongation of QTc (about 8 msec), concomitant use with other drugs that are known to cause QTc prolongation should be avoided, these including antipsychotic medications (e.g., chlorpromazine, haloperidol, thioridazine, ziprasidone), antibiotics (e.g., moxifloxacin), Class 1A (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) antiarrhythmic medications or any other medications known to prolong the QTc interval. 7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by...

Mechanism: Both drugs can cause a dangerous change in the heart's rhythm and increase the risk of serious movement problems.

What to do: You should avoid taking these drugs together to prevent heart rhythm issues and severe muscle side effects.

Ziprasidone at a dose of 20 mg twice daily did not affect the pharmacokinetics of concomitantly administered oral contraceptives, ethinyl estradiol (0.03 mg) and levonorgestrel (0.15 mg).

Mechanism: Ziprasidone does not change the way the body breaks down or removes estradiol from the system. This means the levels of the hormone in your blood stay the same.

What to do: You can safely take these medications together without needing to adjust your dose. Your birth control or hormone therapy should work as expected.

7.9 Other Concomitant Drug Therapy Population pharmacokinetic analysis of schizophrenic patients enrolled in controlled clinical trials has not revealed evidence of any clinically significant pharmacokinetic interactions with benztropine, propranolol, or lorazepam.

Mechanism: Studies of patients show that these two drugs do not have a significant effect on how the body handles either medication. They do not change each other's levels in the body.

What to do: No special precautions or dose changes are typically required when using these drugs at the same time.