Doxycycline and Carbamazepine Interaction
Drug interaction information between Doxycycline and Carbamazepine.
Doxycycline and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxycycline and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to process and get rid of doxycycline faster than it should.
FDA Label Information
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Doxycycline Also Interacts With
- Tetracycline moderate
- Rifampin moderate
- Bismuth Subsalicylate minor
- Phenytoin minor
- Doxycycline Hyclate minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Doxycycline + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Doxycycline's 9. In the minor band specifically: Doxycycline has 7 (also Bismuth Subsalicylate, Phenytoin, Doxycycline Hyclate, Ethinyl Estradiol); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Doxycycline and Carbamazepine?
Carbamazepine causes your body to process and get rid of doxycycline faster than it should.
Carbamazepine carries more major-labeled pairs than Doxycycline
SPL source-record counts only. This page's band is minor · classes on file: Doxycycline (Tetracycline Antibiotic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Doxycycline's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Doxycycline
- Bismuth Subsalicylate
- Phenytoin
- Doxycycline Hyclate
- Ethinyl Estradiol
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.