Oxycodone and Carbamazepine Interaction
Drug interaction information between Oxycodone and Carbamazepine.
Oxycodone and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Carbamazepine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications can slow down your brain and body functions. When used together, they can cause dangerously low blood pressure, extreme sleepiness, or breathing problems.
What To Do
Use these drugs together only if necessary and watch closely for signs of severe drowsiness or slow breathing.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .
Oxycodone Also Interacts With
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
- Phenytoin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Oxycodone and Carbamazepine together?
This is a moderate interaction. Use these drugs together only if necessary and watch closely for signs of severe drowsiness or slow breathing.
How serious is the interaction between Oxycodone and Carbamazepine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Oxycodone and Carbamazepine interact?
Both of these medications can slow down your brain and body functions. When used together, they can cause dangerously low blood pressure, extreme sleepiness, or breathing problems.
Understanding the Oxycodone and Carbamazepine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Oxycodone belongs to the Opioid Analgesic class and Carbamazepine belongs to the Anticonvulsant class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications can slow down your brain and body functions. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Oxycodone has 28 total documented interactions on file in this dataset, and Carbamazepine has 129. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use these drugs together only if necessary and watch closely for signs of severe drowsiness or slow breathing. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Oxycodone or Carbamazepine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.