Oxycodone and Carbamazepine Interaction
Drug interaction information between Oxycodone and Carbamazepine.
Oxycodone and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can slow down your brain and body functions. When used together, they can cause dangerously low blood pressure, extreme sleepiness, or breathing problems.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .
Oxycodone Also Interacts With
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
- Phenytoin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Oxycodone's 28. In the moderate band specifically: Oxycodone has 6 (also Rifampin, Buprenorphine, Butorphanol, Nalbuphine); Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone).
What mechanism field is on file for Oxycodone and Carbamazepine?
Both of these medications can slow down your brain and body functions. When used together, they can cause dangerously low blood pressure, extreme sleepiness, or breathing problems.
Carbamazepine carries more major-labeled pairs than Oxycodone
SPL source-record counts only. This page's band is moderate · classes on file: Oxycodone (Opioid Analgesic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Oxycodone's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 22 minor · 28 total
- Other moderate peers for Oxycodone
- Rifampin
- Buprenorphine
- Butorphanol
- Nalbuphine
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.