Carbamazepine and Citalopram Interaction
Drug interaction information between Carbamazepine and Citalopram.
Carbamazepine and Citalopram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbamazepine and Citalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your body break down citalopram faster, which lowers the amount of medicine available to work.
FDA Label Information
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Citalopram Also Interacts With
- Linezolid major
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Citalopram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Citalopram's 9. In the minor band specifically: Carbamazepine has 110 (also Omeprazole, Ibuprofen, Amitriptyline, Acetaminophen); Citalopram has 4 (also Buspirone, Lithium, Sertraline).
What mechanism field is on file for Carbamazepine and Citalopram?
Carbamazepine makes your body break down citalopram faster, which lowers the amount of medicine available to work.
Carbamazepine's labeled portfolio outnumbers Citalopram
SPL source-record counts only. This page's band is minor · classes on file: Carbamazepine (Anticonvulsant); Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Amitriptyline
- Acetaminophen
3 major · 2 moderate · 4 minor · 9 total
- Other minor peers for Citalopram
- Buspirone
- Lithium
- Sertraline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.