What the FDA labels say about taking them together
Apremilast and carbamazepine
Apremilast's FDA label of September 2, 2026 names carbamazepine in its warnings and precautions section; the carbamazepine labels PlainMeds reads (3) do not name apremilast. The apremilast label: “Use with strong cytochrome P450 enzyme inducers is not recommended because loss of efficacy may occur”
Check it at the source: the apremilast FDA label on DailyMed (effective September 2, 2026, Amgen, Inc); the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation).
What does the apremilast label say about carbamazepine?
Apremilast label, warnings and precautionsUse with strong cytochrome P450 enzyme inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended because loss of efficacy may occur
Source: FDA drug label (Otezla), Amgen, Inc, effective September 2, 2026 (SPL set f6b1f516-4972-4d82-bced-113e47b41cc5), via openFDA; the full label on DailyMed
What does the carbamazepine label say about apremilast?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name apremilast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apremilast | Carbamazepine | |
|---|---|---|
| Labeled for | Psoriasis | Bipolar disorder, Seizures and epilepsy |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $90.57 per tablet 30 mg tablet | $0.119 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once