What the FDA labels say about taking them together
Aripiprazole and carbamazepine
Aripiprazole's FDA label of January 29, 2025 names carbamazepine in its drug interactions section, and carbamazepine's label names aripiprazole too. The aripiprazole label: “Increase the ABILIFY dosage when administered concomitantly with a strong CYP3A4 inducer.”
Check it at the source: the aripiprazole FDA label on DailyMed (effective January 29, 2025, Otsuka America Pharmaceutical, Inc.); the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation).
What does the aripiprazole label say about carbamazepine?
Aripiprazole label, drug interactionsConcomitant Drug Name or Drug Class: Strong CYP3A4 Inducers (e.g., carbamazepine, rifampin); Clinical Rationale: Concomitant use of ABILIFY and carbamazepine decreased the exposure of aripiprazole compared to the use of ABILIFY alone [see ].; Clinical Recommendation: Increase the ABILIFY dosage when administered concomitantly with a strong CYP3A4 inducer [see ].
Abilify Maintena label (Otsuka America Pharmaceutical, Inc., March 24, 2026), drug interactionsStrong CYP3A4 Inducers (e.g., carbamazepine) The concomitant use of oral aripiprazole and carbamazepine decreased the exposure of aripiprazole [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Abilify Maintena, NDA202971), Otsuka America Pharmaceutical, Inc., effective March 24, 2026 (SPL set ee49f3b1-1650-47ff-9fb1-ea53fe0b92b6), via openFDA
Source: FDA drug label (Opipza, NDA216655), Carwin Pharmaceutical Associates, LLC, effective January 30, 2025 (SPL set b47ede68-8942-4432-af7e-57afc14b2ba4), via openFDA
Source: FDA drug label (Abilify Asimtufii, NDA217006), Otsuka America Pharmaceutical, Inc, effective April 4, 2025 (SPL set da4c07fd-1130-4341-bb44-63acfa4162be), via openFDA
Source: FDA drug label (ABILIFY), Otsuka America Pharmaceutical, Inc., effective January 29, 2025 (SPL set c040bd1d-45b7-49f2-93ea-aed7220b30ac), via openFDA; the full label on DailyMed
What does the carbamazepine label say about aripiprazole?
Carbamazepine label, drug interactionsWhen carbamazepine is added to aripiprazole, the aripiprazole dose should be doubled.
Source: FDA drug label (Equetro, NDA021710), Validus Pharmaceuticals LLC, effective August 19, 2025 (SPL set be478f3c-40f6-47cc-8ab9-f420a9372b1c), via openFDA
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole | Carbamazepine | |
|---|---|---|
| Labeled for | Depression, Bipolar disorder, Schizophrenia | Bipolar disorder, Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.110 per tablet 5 mg tablet | $0.119 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once