Carbamazepine and Lithium Interaction
Drug interaction information between Carbamazepine and Lithium.
Carbamazepine and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Carbamazepine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these two medications can increase the risk of toxic effects on your brain and nervous system.
FDA Label Information
Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Apixaban moderate
- Desmopressin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Lithium's 90. In the moderate band specifically: Carbamazepine has 16 (also Apixaban, Desmopressin, Dronedarone, Fluconazole); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Carbamazepine and Lithium?
Combining these two medications can increase the risk of toxic effects on your brain and nervous system.
Carbamazepine carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is moderate · classes on file: Carbamazepine (Anticonvulsant); Lithium (Mood Stabilizer).
Carbamazepine has 3 major-labeled pairs vs Lithium's 2. This page itself is in the moderate band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Apixaban
- Desmopressin
- Dronedarone
- Fluconazole
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.