What the FDA labels say about taking them together
Carbamazepine and donepezil/memantine
Donepezil/memantine's FDA label of December 17, 2024 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name donepezil/memantine. The donepezil/memantine label: “Inducers of CYP3A4 could increase the rate of elimination of donepezil.”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the donepezil/memantine FDA label on DailyMed (effective December 17, 2024, Amneal Pharmaceuticals NY LLC).
What does the carbamazepine label say about donepezil/memantine?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name donepezil/memantine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the donepezil/memantine label say about carbamazepine?
Donepezil/memantine label, drug interactionsInducers of CYP3A4 (e.g., phenytoin, carbamazepine, dexamethasone, rifampin, and phenobarbital) could increase the rate of elimination of donepezil.
Source: FDA drug label (Memantine and Donepezil Hydrochlorides Extended-release), Amneal Pharmaceuticals NY LLC, effective December 17, 2024 (SPL set 2335950c-be3b-4248-ad04-e9763aee47d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Donepezil/memantine | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | Alzheimer's disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $8.44 per unit 28-10 mg |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once