What the FDA labels say about taking them together
Carbamazepine and cobimetinib
Cobimetinib's FDA label of July 29, 2026 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name cobimetinib. The cobimetinib label: “Avoid concurrent use of COTELLIC and strong or moderate CYP3A inducers including but not limited to carbamazepine, efavirenz, phenytoin, rifampin, and St. John's Wort.”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the cobimetinib FDA label on DailyMed (effective July 29, 2026, Genentech, Inc.).
What does the carbamazepine label say about cobimetinib?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name cobimetinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the cobimetinib label say about carbamazepine?
Cobimetinib label, drug interactionsAvoid concurrent use of COTELLIC and strong or moderate CYP3A inducers including but not limited to carbamazepine, efavirenz, phenytoin, rifampin, and St. John's Wort [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Cotellic), Genentech, Inc., effective July 29, 2026 (SPL set c387579e-cee0-4334-bd1e-73f93ac1bde6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Cobimetinib | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once