Fentanyl and Carbamazepine Interaction
Drug interaction information between Fentanyl and Carbamazepine.
Fentanyl and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fentanyl and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can cause a drop in blood pressure and lower the pressure in your lungs. This can make you feel dizzy, weak, or lightheaded.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: The concomitant use of Fentanyl Citrate Injection with CNS depressants may result in decreased pulmonary artery pressure and may cause hypotension.
Fentanyl Also Interacts With
- Itraconazole moderate
- Tranylcypromine moderate
- Tramadol minor
- Cyclobenzaprine minor
- Ketoconazole minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Fentanyl + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Fentanyl's 28. In the minor band specifically: Fentanyl has 26 (also Tramadol, Cyclobenzaprine, Ketoconazole, Diazepam); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Fentanyl and Carbamazepine?
Using these two drugs together can cause a drop in blood pressure and lower the pressure in your lungs. This can make you feel dizzy, weak, or lightheaded.
Carbamazepine carries more major-labeled pairs than Fentanyl
SPL source-record counts only. This page's band is minor · classes on file: Fentanyl (Opioid Analgesic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Fentanyl's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 26 minor · 28 total
- Other minor peers for Fentanyl
- Tramadol
- Cyclobenzaprine
- Ketoconazole
- Diazepam
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.