What the FDA labels say about taking them together
Carbamazepine and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names carbamazepine in its contraindications section; the carbamazepine labels PlainMeds reads (3) do not name rilpivirine. The rilpivirine label: “Coadministration is contraindicated with EDURANT or EDURANT PED.”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the carbamazepine label say about rilpivirine?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the rilpivirine label say about carbamazepine?
Rilpivirine label, contraindicationsDrug Class: Anticonvulsants; Contraindicated Drugs in Class: Carbamazepine Oxcarbazepine Phenobarbital Phenytoin; Clinical Comment: Potential for significant decreases in rilpivirine plasma concentrations due to CYP3A enzyme induction, which may result in loss of virologic response.
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Anticonvulsants: carbamazepine oxcarbazepine phenobarbital phenytoin; Effect on Concentration of Rilpivirine or Concomitant Drug: ↓ rilpivirine; Clinical Comment: Coadministration is contraindicated with EDURANT or EDURANT PED [see ].
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Rilpivirine | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once