Quetiapine and Carbamazepine Interaction
Drug interaction information between Quetiapine and Carbamazepine.
Quetiapine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Quetiapine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up the process your body uses to get rid of quetiapine. This causes the amount of quetiapine in your system to drop, which may make the drug less effective.
FDA Label Information
Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St.
Quetiapine Also Interacts With
- Clarithromycin major
- Darunavir moderate
- Ketoconazole minor
- Rifampin minor
- Itraconazole minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Quetiapine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Quetiapine's 9. In the minor band specifically: Quetiapine has 7 (also Ketoconazole, Rifampin, Itraconazole, Dopamine); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Quetiapine and Carbamazepine?
Carbamazepine speeds up the process your body uses to get rid of quetiapine. This causes the amount of quetiapine in your system to drop, which may make the drug less effective.
Carbamazepine carries more major-labeled pairs than Quetiapine
SPL source-record counts only. This page's band is minor · classes on file: Quetiapine (Atypical Antipsychotic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Quetiapine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Quetiapine
- Ketoconazole
- Rifampin
- Itraconazole
- Dopamine
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.