What the FDA labels say about taking them together
Carbamazepine and etravirine
Etravirine's FDA label of August 15, 2023 names carbamazepine in its drug interactions section; the carbamazepine labels PlainMeds reads (3) do not name etravirine. The etravirine label: “Carbamazepine, phenobarbital and phenytoin are inducers of CYP450 enzymes. INTELENCE should not be used in combination with carbamazepine, phenobarbital, or phenytoin as co-administration may cause significant decreases …”
Check it at the source: the carbamazepine FDA label on DailyMed (effective August 20, 2026, Novartis Pharmaceuticals Corporation); the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP).
What does the carbamazepine label say about etravirine?
Carbamazepine's label (effective August 20, 2026) and its 2 other brand-application labels do not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tegretol), Novartis Pharmaceuticals Corporation, effective August 20, 2026 (SPL set 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053), via openFDA; the full label on DailyMed
What does the etravirine label say about carbamazepine?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: Anticonvulsants: carbamazepine phenobarbital phenytoin; Effect on Concentration of Etravirine or Concomitant Drug: ↓ etravirine; Clinical Comment: Carbamazepine, phenobarbital and phenytoin are inducers of CYP450 enzymes. INTELENCE should not be used in combination with carbamazepine, phenobarbital, or phenytoin as co-administration may cause significant decreases in etravirine plasma concentrations and loss of therapeutic effect of INTELENCE.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbamazepine | Etravirine | |
|---|---|---|
| Labeled for | Bipolar disorder, Seizures and epilepsy | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.119 per tablet 200 mg tablet | $9.94 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once