Rivaroxaban and Carbamazepine Interaction
Drug interaction information between Rivaroxaban and Carbamazepine.
Rivaroxaban and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rivaroxaban and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to process rivaroxaban too quickly, which may prevent the drug from protecting you against blood clots.
FDA Label Information
7.3 Drugs that Induce Cytochrome P450 3A Enzymes and Drug Transport Systems Avoid concomitant use of XARELTO with drugs that are combined P-gp and strong CYP3A inducers (e.g., carbamazepine, phenytoin, rifampin, St.
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Erythromycin moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Rivaroxaban + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Rivaroxaban has 13 (also Clopidogrel, Aspirin, Warfarin, Ketoconazole); Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone).
What mechanism field is on file for Rivaroxaban and Carbamazepine?
Carbamazepine causes your body to process rivaroxaban too quickly, which may prevent the drug from protecting you against blood clots.
Carbamazepine carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Rivaroxaban's 0. This page itself is in the moderate band, not the major band.
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Aspirin
- Warfarin
- Ketoconazole
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.