Clonazepam and Carbamazepine Interaction
Drug interaction information between Clonazepam and Carbamazepine.
Clonazepam and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonazepam and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how fast your body processes clonazepam. This can lower the amount of clonazepam in your blood and make it less effective.
FDA Label Information
Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of carbamazepine or phenobarbital. Cytochrome P450 inducers, such as phenytoin, carbamazepine, lamotrigine, and phenobarbital induce clonazepam metabolism, causing an approximately 38% decrease in plasma clonazepam levels.
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Clonazepam + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Clonazepam's 14. In the minor band specifically: Clonazepam has 10 (also Lamotrigine, Fluconazole, Ranitidine, Phenytoin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Clonazepam and Carbamazepine?
Carbamazepine speeds up how fast your body processes clonazepam. This can lower the amount of clonazepam in your blood and make it less effective.
Carbamazepine's labeled portfolio outnumbers Clonazepam
SPL source-record counts only. This page's band is minor · classes on file: Clonazepam (Benzodiazepine); Carbamazepine (Anticonvulsant).
3 major · 1 moderate · 10 minor · 14 total
- Other minor peers for Clonazepam
- Lamotrigine
- Fluconazole
- Ranitidine
- Phenytoin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.