Risperidone and Carbamazepine Interaction
Drug interaction information between Risperidone and Carbamazepine.
Risperidone and Carbamazepine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Risperidone and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how fast your body breaks down risperidone, which lowers the amount of medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. ( 7.1 ) 7.1 Pharmacokinetic-related Interactions The dose of risperidone tablets should be adjusted when used in combination with CYP2D6 enzyme inhibitors (e.g., fluoxetine, and paroxetine) and enzyme inducers (e.g., carbamazepine) [see Table 18 and Dosage and Administration (2.5) ]. Do not exceed 8 mg/day 20 mg/day 4 mg/day 1.6 - 40 mg/day 4 mg/day 1.8 - Enzyme (CYP3A/ PgP inducers) Inducers Carbamazepine 573 ± 168 mg/day 3 mg twice daily 0.51 0.55 Titrate dose upwards.
Risperidone Also Interacts With
- Amitriptyline major
- Lithium major
- Erythromycin major
- Ranitidine major
- Cimetidine major
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Lithium moderate
- Apixaban moderate
- Desmopressin moderate
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Carbamazepine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Risperidone's 20. In the major band specifically: Risperidone has 6 (also Amitriptyline, Lithium, Erythromycin, Ranitidine); Carbamazepine has 3 (also Nirmatrelvir/Ritonavir, Ranolazine).
What mechanism field is on file for Risperidone and Carbamazepine?
Carbamazepine speeds up how fast your body breaks down risperidone, which lowers the amount of medicine in your blood.
Risperidone carries more major-labeled pairs than Carbamazepine
SPL source-record counts only. This page's band is major · classes on file: Risperidone (Atypical Antipsychotic); Carbamazepine (Anticonvulsant).
Risperidone has 6 major-labeled pairs vs Carbamazepine's 3.
6 major · 5 moderate · 9 minor · 20 total
- Other major peers for Risperidone
- Amitriptyline
- Lithium
- Erythromycin
- Ranitidine
3 major · 16 moderate · 110 minor · 129 total
- Other major peers for Carbamazepine
- Nirmatrelvir/Ritonavir
- Ranolazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.