Alprazolam and Carbamazepine Interaction
Drug interaction information between Alprazolam and Carbamazepine.
Alprazolam and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alprazolam and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how fast your body breaks down alprazolam. This can make alprazolam less effective because there is not enough of it in your blood.
FDA Label Information
Examples Carbamazepine, phenytoin Ritonavir Clinical implication Interactions involving ritonavir and alprazolam are complex and time dependent.
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Alprazolam + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Erythromycin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Alprazolam and Carbamazepine?
Carbamazepine speeds up how fast your body breaks down alprazolam. This can make alprazolam less effective because there is not enough of it in your blood.
Carbamazepine carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Alprazolam (Benzodiazepine); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Erythromycin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.