Olanzapine and Carbamazepine Interaction
Drug interaction information between Olanzapine and Carbamazepine.
Olanzapine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Olanzapine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes the liver to break down olanzapine much faster than usual. This lowers the amount of medicine in your blood and may stop it from working.
FDA Label Information
( 7.1 ) Carbamazepine: Increased clearance of olanzapine. Inducers of CYP1A2 — Carbamazepine therapy (200 mg bid) causes an approximately 50% increase in the clearance of olanzapine. This increase is likely due to the fact that carbamazepine is a potent inducer of CYP1A2 activity.
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Olanzapine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Olanzapine's 26. In the minor band specifically: Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Lithium); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Olanzapine and Carbamazepine?
Carbamazepine causes the liver to break down olanzapine much faster than usual. This lowers the amount of medicine in your blood and may stop it from working.
Carbamazepine carries more major-labeled pairs than Olanzapine
SPL source-record counts only. This page's band is minor · classes on file: Olanzapine (Atypical Antipsychotic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Olanzapine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Lithium
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.