Prescription medicine
Diltiazem Brand names: Cardizem, Tiazac, Tiadylt, Cartia, Matzim
Diltiazem (Cardizem) is a prescription medicine with an FDA approval on record since 1982. FDA's NDC Directory lists it from 50 generic labelers, and pharmacies paid $0.144 per diltiazem 24h ER(cd) 120 mg capsule in the October 7, 2026 NADAC survey.
- Generic listed
- A presentation discontinued
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the NDA 18602 record on Drugs@FDA; every diltiazem label on DailyMed.
Highlights of the record
FDA label of August 7, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageHypertension Tiazac is indicated for the treatment of hypertension.
Forms and strengths
- 30 mg
- 60 mg
- 90 mg
- 100 mg
- 120 mg
- 180 mg
- 240 mg
- 300 mg
- 360 mg
- 420 mg
- 1 mg/ml
- 5 mg/ml
Extended-release capsule; extended-release tablet; tablet; film-coated tablet; coated extended-release capsule.
On the market
- Earliest approval on file
- November 5, 1982 Cardizem, Bausch; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 59 first November 5, 1992; 35 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 54 of which 50 under generic applications, 3 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.144 per capsule Diltiazem 24h ER(cd) 120 mg capsule
- Shortage (FDA)
- None current 1 past records
- Recalls by its makers (FDA)
- 29 since 2013 0 Class I among all firms' recalls; latest March 13, 2025; 10 more by firms not listed as its makers
- FAERS reports
- 34,213 through July 30, 2026
What is diltiazem used for?
From the label: indications and usageHypertension Tiazac is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive medications. Chronic Stable Angina Tiazac is indicated for the treatment of chronic stable angina.
Conditions named in the indications of diltiazem's FDA labels, with every medicine labeled for each:
From other diltiazem labelsHigh blood pressure: INDICATIONS AND USAGE Hypertension Tiazac is indicated for the treatment of hypertension.
Atrial fibrillation: Atrial Fibrillation or Atrial Flutter Temporary control of rapid ventricular rate in atrial fibrillation or atrial flutter.
FDA pharmacologic class: Calcium Channel Blocker.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
Is there a generic for diltiazem (Cardizem)?
The FDA approved the first generic diltiazem on November 5, 1992. 59 generic applications are approved; 35 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists diltiazem from 50 labelers under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1982 earliest approval on file
- 1992 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for diltiazem (Cardizem)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.144 per Diltiazem 24h ER(cd) 120 mg capsule, down 4% from $0.150 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Diltiazem 24h ER(cd) 120 mg capsule (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Cartia xt 120 mg capsule | Generic | $0.144 per capsule | $4.31 | -4% |
| Cartia xt 180 mg capsule | Generic | $0.187 per capsule | $5.62 | +3% |
| Cartia xt 240 mg capsule | Generic | $0.197 per capsule | $5.91 | -9% |
| Cartia xt 300 mg capsule | Generic | $0.302 per capsule | $9.06 | +0.9% |
| Dilt XR 120 mg capsule | Generic | $0.311 per capsule | $9.32 | -22% |
| Dilt XR 180 mg capsule | Generic | $0.366 per capsule | $10.99 | -25% |
| Dilt XR 240 mg capsule | Generic | $0.489 per capsule | $14.66 | -24% |
| Diltiazem 120 mg tablet | Generic | $0.099 per tablet | $2.97 | -9% |
| Diltiazem 12hr ER 120 mg capsule | Generic | $1.97 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $59.11 | -19% |
| Diltiazem 12hr ER 60 mg capsule | Generic | $1.43 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $42.80 | -2% |
| Diltiazem 12hr ER 90 mg capsule | Generic | $1.66 per capsule many times the lowest per-tablet cost; NADAC records the price, not why | $49.84 | -8% |
| Diltiazem 24h ER(cd) 120 mg capsule | Generic | $0.144 per capsule | $4.31 | -4% |
| Diltiazem 24h ER(cd) 180 mg capsule | Generic | $0.187 per capsule | $5.62 | +3% |
| Diltiazem 24h ER(cd) 240 mg capsule | Generic | $0.197 per capsule | $5.91 | -9% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Is diltiazem in shortage?
No diltiazem presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 1 record is all marked to be discontinued, the latest updated January 5, 2026. ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Diltiazem Hydrochloride, Injection, 100 mg Single Dose ADD-Vantage® Glass Vial (NDC 0409-4350-03) | Hospira, Inc., a Pfizer Company | To Be Discontinued | January 5, 2026 |
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
Has diltiazem been recalled?
The FDA's Enforcement Report lists 39 recalls naming diltiazem since 2013: 0 Class I (the most serious), 25 Class II, 14 Class III; 9 still ongoing. 10 of them are by firms that FDA's NDC Directory does not list as a maker of diltiazem and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| March 13, 2025 | Class II | Glenmark Pharmaceuticals Inc., USA | CGMP Deviations |
| November 1, 2024 | Class II | Glenmark Pharmaceuticals Inc., USA | cGMP Deviations: Presence of N-nitroso-Desmethyl-Diltiazem impurity above FDA recommended interim limit. |
| April 17, 2024 | Class II | Glenmark Pharmaceuticals Inc., USA | Failed Dissolution Specifications |
| March 26, 2024 | Class II | Glenmark Pharmaceuticals Inc., USA | Failed Dissolution Specifications: Out of Specification (OOS) was reported in test of dissolution at the 12th month time point in long term stability study. |
| November 9, 2023 | Class II | SCA Pharmaceuticals, LLC | Lack of Assurance of Sterility |
| August 17, 2023 | Class II | Central Admixture Pharmacy Services, Inc. | Lack of Assurance of Sterility:Lack of validation data for sanitization cycles |
| July 14, 2023 | Class II | Central Admixture Pharmacy Services, Inc. | Lack of assurance of sterility. Validation data for decontamination cycles is lacking. |
| January 13, 2023 | Class II | SUN PHARMACEUTICAL INDUSTRIES INC | Failed Impurity (Deacetyl Diltiazem Hydrochloride) specification during stability testing and failed dissolution testing at FDA laboratory. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the diltiazem label say about other medicines?
The diltiazem label names 16 other medicines in its interaction, contraindication or warning sections. The labels of 50 other medicines name diltiazem. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Buspirone | drug interactions | In nine healthy subjects, diltiazem significantly increased the mean buspirone AUC 5.5-fold and C max 4.1-fold compared to placebo. |
| Carbamazepine | drug interactions | Carbamazepine: Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases. |
| Cimetidine | drug interactions | A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60 mg. Ranitidine produced smaller, nonsignificant increases. |
| Clonidine | drug interactions | Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concurrently with diltiazem. |
| Cyclosporine | drug interactions | In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem. |
| Digoxin | drug interactions | Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. |
| Ivabradine | drug interactions | Concurrent use of diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. |
| Lovastatin | drug interactions | In a ten-subject randomized, open-label, 4-way cross-over study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone. |
| Midazolam | drug interactions | Benzodiazepines: Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the C max by 2-fold, compared to placebo. |
| Pravastatin | drug interactions | In the same study, there was no significant change in 20 mg single dose pravastatin AUC and C max during diltiazem coadministration. |
| Propranolol | drug interactions | Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. |
| Quinidine | drug interactions | Diltiazem significantly increases the AUC (0→∞) of quinidine by 51%, T ½ by 36%, and decreases its CL oral by 33%. |
| Ranitidine | drug interactions | A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60 mg. Ranitidine produced smaller, nonsignificant increases. |
| Rifampin | drug interactions | Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. |
Every other medicine the diltiazem label names
| Medicine named | Section | What the label says |
|---|---|---|
| Simvastatin | drug interactions | In a healthy volunteer cross-over study (N=10), coadministration of a single 20 mg dose of simvastatin at the end of a 14-day regimen with 120 mg BID diltiazem SR resulted in a 5-fold increase in … |
| Triazolam | drug interactions | Benzodiazepines: Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the C max by 2-fold, compared to placebo. |
Other labels that name diltiazem
- Amiodarone
- Amlodipine
- Aprepitant
- Atazanavir
- Atenolol
- Betaxolol
- Bisoprolol
- Bosentan
- Carvedilol
- Cilostazol
- Clarithromycin
- Cobicistat
- Colchicine
- Darifenacin
- Darunavir
- Dienogest and estradiol
- Dronedarone
- Drospirenone and estradiol
- Drospirenone and ethinyl estradiol
- Drospirenone and ethinyl estradiol and levomefolate
- Dutasteride
- Efavirenz and lamivudine and tenofovir disoproxil
- Erythromycin
- Fesoterodine
- Fluvoxamine
- Fosamprenavir
- Fosaprepitant
- Itraconazole
- Lurasidone
- Magnesium sulfate
- Mavacamten
- Metoprolol
- Naldemedine
- Naloxegol
- Nebivolol
- Nevirapine
- Ponesimod
- Ritonavir
- Silodosin
- Siponimod
- Sirolimus
- Sotalol
- Tacrolimus
- Voclosporin
- Warfarin
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What do FAERS reports show for diltiazem?
The FDA Adverse Event Reporting System holds 34,213 reports that list diltiazem among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 5,131 are coded as a death and 14,554 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as diltiazem?
73 other medicines are given the same way (oral) and in the same FDA class as diltiazem or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Amlodipine | High blood pressure, Angina | 42 labelers | $0.0102 per tablet 5 mg tablet | No current entry |
| Amlodipine and benazepril | High blood pressure | 16 labelers | $0.114 per unit 10-20 mg | No current entry |
| Verapamil | High blood pressure, Atrial fibrillation, Angina | 24 labelers | $0.191 per tablet 180 mg tablet | A presentation being discontinued |
| Amlodipine and atorvastatin | High blood pressure, Angina | 6 labelers | $1.34 per unit 10-40 mg | No current entry |
| Amlodipine and olmesartan | High blood pressure | 14 labelers | $0.248 per unit 10-20 mg | No current entry |
| Amlodipine and hydrochlorothiazide and olmesartan | High blood pressure | 8 labelers | $0.776 per unit 20-5-12.5 | No current entry |
| Amlodipine and valsartan | High blood pressure | 9 labelers | $0.330 per unit 10-160 mg | No current entry |
| Amlodipine and hydrochlorothiazide and valsartan | High blood pressure | 5 labelers | $6.09 per tablet 10-160-25 mg tablet | No current entry |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does diltiazem compare with medicines for the same use?
17 side-by-side pages set diltiazem beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to diltiazem
- 73 medicines for the same use
- Other calcium channel blockers
- the pharmacologic class, with prices and generics
- Diltiazem side effects
- the label's list beside FAERS reports
- Diltiazem shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other