Prescription medication · Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)
bupropion
Also sold as Wellbutrin, Zyban. Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating.
Data updated 2026-05-15
- 41,778
- FDA reportsOften reported
- 35
- InteractionsSeveral interactions
- 2
- Recall records
What the data shows
bupropion (Wellbutrin) is a prescription Norepinephrine-Dopamine Reuptake Inhibitor (NDRI), reported at a middle-of-the-pack volume (41,778 FDA reports), with 35 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
bupropion (Wellbutrin) is a prescription Norepinephrine-Dopamine Reuptake Inhibitor (NDRI). Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating.
Bupropion is a medicine used to treat depression and prevent seasonal affective disorder (SAD). It can help improve your mood and energy levels.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.11/unit
Generic Available
Yes (41 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating.
Common side effects
Dry mouth, Nausea, Trouble sleeping
Key warnings
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults.
The sections below are summarized in plain English from bupropion's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Bupropion works by affecting certain chemicals in the brain called norepinephrine and dopamine. It helps to increase the levels of these chemicals, which can improve mood and reduce symptoms of depression.
Side Effects (from patient reports)
Based on 41,778 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for bupropion, by number of reports
- Completed Suicide
Completed Suicide
4,408 reports
- Toxicity To Various Agents
Toxicity To Various Agents
3,113 reports
- Fatigue
Fatigue
2,665 reports
- Nausea
Nausea
2,309 reports
- Headache
Headache
2,218 reports
- Depression
Depression
2,175 reports
- Pain
Pain
1,955 reports
- Overdose
Overdose
1,855 reports
- Drug Interaction 1,690
Drug Interaction
1,690 reports
- Anxiety 1,678
Anxiety
1,678 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for bupropion each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where bupropion sits
bupropion has more FDA adverse-event reports than 70% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is bupropion; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 41,778 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
41,778
Reports Mentioning Death
8,506
20.4% of reports — not proof of cause
Hospitalization Reports
13,230
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | COMPLETED SUICIDE | 4,408 |
| 3 | TOXICITY TO VARIOUS AGENTS | 3,113 |
| 4 | FATIGUE | 2,665 |
| 5 | NAUSEA | 2,309 |
| 7 | HEADACHE | 2,218 |
| 8 | DEPRESSION | 2,175 |
| 9 | PAIN | 1,955 |
| 10 | OVERDOSE | 1,855 |
| 11 | DRUG INTERACTION | 1,690 |
| 12 | ANXIETY | 1,678 |
| 13 | DIZZINESS | 1,579 |
| 14 | DIARRHOEA | 1,522 |
| 15 | INTENTIONAL OVERDOSE | 1,352 |
| 16 | DYSPNOEA | 1,241 |
| 17 | HYPERTENSION | 1,230 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior.
Known Drug Interactions
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Mechanism: These two antidepressants can cause a severe reaction when used at the same time. They both change brain chemicals in a way that can lead to dangerously high blood pressure.
7.3 Drugs That Lower Seizure Threshold Use extreme caution when coadministering bupropion hydrochloride extended-release tablets (XL) with other drugs that lower the seizure threshold (e.g., other bupropion products, antipsychotics, antidepressants, theophylline, or systemic corticosteroids).
Mechanism: Both of these medicines can increase the risk of having a seizure. Taking them at the same time makes this risk even higher.
Bupropion Use with Caution Concomitant administration of CRESEMBA and bupropion results in decrease in bupropion exposure. Dose increase of bupropion may be necessary when coadministered with CRESEMBA, but should not exceed the maximum recommended dose [see Clinical Pharmacology ( 12.3 )] .
Mechanism: Taking isavuconazonium can lower the amount of bupropion in your system, making the medication less effective. This happens because the body clears the drug faster than normal.
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Mechanism: Bupropion blocks a liver enzyme that normally breaks down metoprolol. This causes the amount of metoprolol in your blood to rise to higher levels than expected.
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Mechanism: Bupropion slows down the process your liver uses to clear sertraline from your body. This can cause sertraline to build up in your system, increasing the risk of side effects.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I cut the tablet in half?
Can I take this at night?
What if I feel worse after starting this medicine?
Can I drink alcohol while taking this?
How long does it take for this medicine to work?
Will this medicine make me gain weight?
Can I stop taking this medicine suddenly?
What should I do if I have side effects?
Does this medicine interact with other medicines?
Can this medicine cause seizures?
What are the common side effects of bupropion?
Does bupropion interact with other medications?
What drug class is bupropion?
What pregnancy or breastfeeding source fields are listed for bupropion?
Has bupropion been recalled?
Active Recalls
Failed Tablet/Capsule Specifications
Graviti Pharmaceuticals Private Limited
Failed Dissolution Specifications; the product is dissolving faster than the specified limits.
Amerisource Health Services LLC
Related Medications in Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)
Other drugs grouped near bupropion - same-class peers and common alternatives.
acamprosate
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alprazolam
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amitriptyline
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amphetamine/dextroamphetamine
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aripiprazole
Abilify
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems.
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Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for bupropion: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 41,778.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 20.36%.
- atropine Δ 0.13 pts · 7,881 reports · Anticholinergic 20.23%death share
- amikacin Δ 0.14 pts · 16,238 reports · Aminoglycoside Antibiotic 20.22%death share
- pyridoxine Δ 0.18 pts · 2,439 reports · Vitamin B6 Supplement 20.54%death share
- temazepam Δ 0.30 pts · 36,917 reports · Benzodiazepine (Hypnotic) 20.06%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for bupropion
The FDA label for bupropion (sold under brand names such as Wellbutrin, Zyban) classifies it as a prescription-only medication in the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) class. Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating. Official labeling lists 16 commonly reported side effects, including Dry mouth, Nausea, Trouble sleeping.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 41,778 voluntary reports. The database also lists 35 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.11.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 2 recall records on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: November 25, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages